Complement C3

"Complement C3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.

Descriptor ID	D003176
MeSH Number(s)	D12.776.124.050.140 D12.776.124.486.274.250
Concept/Terms	Complement C3 Complement C3 C3, Complement Complement 3 Complement Component 3 Component 3, Complement C3 Complement Complement, C3 Complement C3 Precursor Complement C3 Precursor C3 Precursor, Complement Precursor, Complement C3 Pro-C3 Pro C3 Precursor-Complement 3 Precursor Complement 3 Pro-Complement 3 Pro Complement 3 C3 Precursor Precursor, C3

Below are MeSH descriptors whose meaning is more general than "Complement C3".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Acute-Phase Proteins [D12.776.124.050]
Complement C3 [D12.776.124.050.140]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement C3 [D12.776.124.486.274.250]

Below are MeSH descriptors whose meaning is more specific than "Complement C3".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C3" by people in this website by year, and whether "Complement C3" was a major or minor topic of these publications.

Bar chart showing 18 publications over 13 distinct years, with a maximum of 3 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	1	3
1999	0	2	2
2001	1	0	1
2002	0	1	1
2004	0	2	2
2006	1	0	1
2008	0	2	2
2009	0	1	1
2010	0	1	1
2011	0	1	1
2012	0	1	1
2021	0	1	1
2023	1	0	1

Below are the most recent publications written about "Complement C3" by people in Profiles.

Garg A, Nanji K, Tai F, Phillips M, Zeraatkar D, Garg SJ, Sadda SR, Kaiser PK, Guymer RH, Sivaprasad S, Wykoff CC, Chaudhary V. The effect of complement C3 or C5 inhibition on geographic atrophy secondary to age-related macular degeneration: A living systematic review and meta-analysis. Surv Ophthalmol. 2024 May-Jun; 69(3):349-361.

View in: PubMed
Mahmoudzadeh R, Hinkle JW, Hsu J, Garg SJ. Emerging treatments for geographic atrophy in age-related macular degeneration. Curr Opin Ophthalmol. 2021 May 01; 32(3):294-300.

View in: PubMed
Hammons AL, Summers CM, Jochems J, Arora JS, Zhang S, Blair IA, Whitehead AS. Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions. Eur J Pharmacol. 2012 Dec 05; 696(1-3):12-7.

View in: PubMed
Colombo MJ, Abraham D, Shibuya A, Alugupalli KR. B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fca/? receptor and in the absence of host cell contact. Immunol Res. 2011 Dec; 51(2-3):249-56.

View in: PubMed
Crow AR, Song S, Suppa SJ, Ma S, Reilly MP, Andre P, McKenzie SE, Lazarus AH. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Blood. 2011 Jan 20; 117(3):971-4.

View in: PubMed
Iwamoto S, Iwamoto AT, Cha J, Clark T, Lu M, Breen C, Bhawan J, Falanga V. The utility of the DNA microarray scanner to simplify the immunofluorescence evaluation of autoimmune bullous diseases. Am J Dermatopathol. 2009 May; 31(3):218-22.

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Giorgini A, Brown HJ, Lock HR, Nimmerjahn F, Ravetch JV, Verbeek JS, Sacks SH, Robson MG. Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies. J Immunol. 2008 Dec 15; 181(12):8745-52.

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Baudino L, Nimmerjahn F, Azeredo da Silveira S, Martinez-Soria E, Saito T, Carroll M, Ravetch JV, Verbeek JS, Izui S. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol. 2008 Feb 01; 180(3):1948-53.

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Kerepesi LA, Hess JA, Nolan TJ, Schad GA, Abraham D. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol. 2006 Apr 01; 176(7):4315-22.

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Moll T, Nitschke L, Carroll M, Ravetch JV, Izui S. A critical role for Fc gamma RIIB in the induction of rheumatoid factors. J Immunol. 2004 Oct 01; 173(7):4724-8.

View in: PubMed

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