Electron Transport Complex IV

"Electron Transport Complex IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.

Descriptor ID	D003576
MeSH Number(s)	D05.500.562.374 D08.811.600.250.687 D08.811.682.285 D12.776.157.530.450.250.875.304 D12.776.543.277.687 D12.776.543.585.450.250.875.484
Concept/Terms	Electron Transport Complex IV Electron Transport Complex IV Ferrocytochrome c Oxygen Oxidoreductase Cytochrome-c Oxidase (Complex IV) Cytochrome Oxidase Oxidase, Cytochrome Cytochrome-c Oxidase Cytochrome c Oxidase Oxidase, Cytochrome-c Signal Peptide p25-Subunit IV Cytochrome Oxidase Signal Peptide p25-Subunit IV Cytochrome Oxidase Signal Peptide p25 Subunit IV Cytochrome Oxidase Pre-CTOX p25 p25 Presequence Peptide-Cytochrome Oxidase p25 Presequence Peptide Cytochrome Oxidase Cytochrome-c Oxidase Subunit III Cytochrome-c Oxidase Subunit III Cytochrome c Oxidase Subunit III Subunit III, Cytochrome Oxidase Cytochrome Oxidase Subunit III Cytochrome-c Oxidase Subunit IV Cytochrome-c Oxidase Subunit IV Cytochrome c Oxidase Subunit IV Cytochrome aa3 Cytochrome aa3 Heme aa3 Cytochrome Oxidase Cytochrome a,a3 Cytochrome c Oxidase Subunit VIa Cytochrome c Oxidase Subunit VIa

Below are MeSH descriptors whose meaning is more general than "Electron Transport Complex IV".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Multienzyme Complexes [D05.500.562]
Electron Transport Complex IV [D05.500.562.374]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Multienzyme Complexes [D08.811.600]
Electron Transport Chain Complex Proteins [D08.811.600.250]
Electron Transport Complex IV [D08.811.600.250.687]
Oxidoreductases [D08.811.682]
Electron Transport Complex IV [D08.811.682.285]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Cation Transport Proteins [D12.776.157.530.450.250]
Proton Pumps [D12.776.157.530.450.250.875]
Electron Transport Complex IV [D12.776.157.530.450.250.875.304]
Membrane Proteins [D12.776.543]
Electron Transport Chain Complex Proteins [D12.776.543.277]
Electron Transport Complex IV [D12.776.543.277.687]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Cation Transport Proteins [D12.776.543.585.450.250]
Proton Pumps [D12.776.543.585.450.250.875]
Electron Transport Complex IV [D12.776.543.585.450.250.875.484]

Below are MeSH descriptors whose meaning is related to "Electron Transport Complex IV".

Below are MeSH descriptors whose meaning is more specific than "Electron Transport Complex IV".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Electron Transport Complex IV" by people in this website by year, and whether "Electron Transport Complex IV" was a major or minor topic of these publications.

Bar chart showing 17 publications over 10 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	2	0	2
2004	1	1	2
2005	1	0	1
2007	1	0	1
2009	1	0	1
2010	2	1	3
2011	0	2	2
2012	1	1	2
2017	2	0	2
2022	0	1	1

Below are the most recent publications written about "Electron Transport Complex IV" by people in Profiles.

Eyenga P, Rey B, Eyenga L, Sheu SS. Regulation of Oxidative Phosphorylation of Liver Mitochondria in Sepsis. Cells. 2022 May 10; 11(10).

View in: PubMed
Hasbrook M, Yonekawa Y, Van Laere L, Shah AR, Capone A. Bilateral persistent fetal vasculature and a chromosome 10 mutation including COX15. Can J Ophthalmol. 2017 12; 52(6):e203-e205.

View in: PubMed
Alleyne T, Ignacio DN, Sampson VB, Ashe D, Wilson M. Simulating the slow to fast switch in cytochrome c oxidase catalysis by introducing a loop flip near the enzyme's cytochrome c (substrate) binding site. Biotechnol Appl Biochem. 2017 Sep; 64(5):677-685.

View in: PubMed
George TJ, Arnaoutakis GJ, Beaty CA, Jandu SK, Santhanam L, Berkowitz DE, Shah AS. Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation. J Surg Res. 2012 Dec; 178(2):593-600.

View in: PubMed
Ashe D, Alleyne T, Sampson V. Substrate binding-dissociation and intermolecular electron transfer in cytochrome c oxidase are driven by energy-dependent conformational changes in the enzyme and substrate. Biotechnol Appl Biochem. 2012 May-Jun; 59(3):213-22.

View in: PubMed
Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Pavlides S, Tsirigos A, Ertel A, Pestell RG, Broda P, Minetti C, Lisanti MP, Sotgia F. Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle. 2011 Dec 1; 10(23):4047-64.

View in: PubMed
Buerk DG, Barbee KA, Jaron D. Nitric oxide signaling in the microcirculation. Crit Rev Biomed Eng. 2011; 39(5):397-433.

View in: PubMed
Mimaki M, Hatakeyama H, Komaki H, Yokoyama M, Arai H, Kirino Y, Suzuki T, Nishino I, Nonaka I, Goto Y. Reversible infantile respiratory chain deficiency: a clinical and molecular study. Ann Neurol. 2010 Dec; 68(6):845-54.

View in: PubMed
Figueroa-Mart?nez F, V?zquez-Acevedo M, Cort?s-Hern?ndez P, Garc?a-Trejo JJ, Davidson E, King MP, Gonz?lez-Halphen D. What limits the allotopic expression of nucleus-encoded mitochondrial genes? The case of the chimeric Cox3 and Atp6 genes. Mitochondrion. 2011 Jan; 11(1):147-54.

View in: PubMed
Masuda I, Matsuzaki M, Kita K. Extensive frameshift at all AGG and CCC codons in the mitochondrial cytochrome c oxidase subunit 1 gene of Perkinsus marinus (Alveolata; Dinoflagellata). Nucleic Acids Res. 2010 Oct; 38(18):6186-94.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement