"Deoxyribonuclease I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
| Descriptor ID |
D003850
|
| MeSH Number(s) |
D08.811.277.352.335.350.250
|
| Concept/Terms |
Deoxyribonuclease I- Deoxyribonuclease I
- DNAase I
- Pancreatic DNase
- DNase, Pancreatic
- Thymonuclease
- DNA Endonuclease
- Endonuclease, DNA
- DNase I
Nickase- Nickase
- DNA Nicking Enzyme
- Endonuclease I
|
Below are MeSH descriptors whose meaning is more general than "Deoxyribonuclease I".
Below are MeSH descriptors whose meaning is more specific than "Deoxyribonuclease I".
This graph shows the total number of publications written about "Deoxyribonuclease I" by people in this website by year, and whether "Deoxyribonuclease I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Deoxyribonuclease I" by people in Profiles.
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Tripathi SK, Gupta N, Mahato M, Gupta KC, Kumar P. Selective blocking of primary amines in branched polyethylenimine with biocompatible ligand alleviates cytotoxicity and augments gene delivery efficacy in mammalian cells. Colloids Surf B Biointerfaces. 2014 Mar 01; 115:79-85.
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Padman R, Flathers K, Passi V. Cystic fibrosis infant care challenges in diagnosis and management in the era of newborn screening. Del Med J. 2012 May; 84(5):149-55.
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Tripathi SK, Yadav S, Gupta KC, Kumar P. Synthesis and evaluation of N-(2,3-dihydroxypropyl)-PEIs as efficient vectors for nucleic acids. Mol Biosyst. 2012 Apr; 8(5):1426-34.
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Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA. Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res. 2007 Apr 1; 313(6):1069-79.
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Castronuevo P, Thornton MA, McCarthy LE, Klimas J, Schick BP. DNase I hypersensitivity patterns of the serglycin proteoglycan gene in resting and phorbol 12-myristate 13-acetate-stimulated human erythroleukemia (HEL), CHRF 288-11, and HL-60 cells compared with neutrophils and human umbilical vein endothelial cells. J Biol Chem. 2003 Dec 05; 278(49):48704-12.
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Heinrichs AA, Bortell R, Rahman S, Stein JL, Alnemri ES, Litwack G, Lian JB, Stein GS. Identification of multiple glucocorticoid receptor binding sites in the rat osteocalcin gene promoter. Biochemistry. 1993 Oct 26; 32(42):11436-44.
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Pestell RG, Hammond VE, Crawford RJ. Molecular cloning and characterization of the cyclic AMP-responsive ovine CYP11A1 (cholesterol side-chain cleavage) gene promoter: DNase 1 protection of conserved consensus elements. J Mol Endocrinol. 1993 Jun; 10(3):297-311.
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Radice G, Costantini F. Tissue-specific DNase I hypersensitive sites in a foreign globin gene in transgenic mice. Nucleic Acids Res. 1986 Dec 22; 14(24):9765-80.
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Costantini F, Radice G, Magram J, Stamatoyannopoulos G, Papayannopoulou T, Chada K. Developmental regulation of human globin genes in transgenic mice. Cold Spring Harb Symp Quant Biol. 1985; 50:361-70.