"Diazooxonorleucine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)
| Descriptor ID |
D003980
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| MeSH Number(s) |
D02.172.508 D12.125.213.568.175
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Diazooxonorleucine".
Below are MeSH descriptors whose meaning is more specific than "Diazooxonorleucine".
This graph shows the total number of publications written about "Diazooxonorleucine" by people in this website by year, and whether "Diazooxonorleucine" was a major or minor topic of these publications.
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Below are the most recent publications written about "Diazooxonorleucine" by people in Profiles.
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Clark CC, Richards CF, Iozzo RV. Post-translational alterations in newly synthesized cartilage proteoglycans induced by the glutamine analogue 6-diazo-5-oxo-L-norleucine. Time course of inhibition and recovery. Biochem J. 1991 Jan 15; 273(Pt 2):283-8.
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Iozzo RV, Clark CC. Modulation of heparan sulfate biosynthesis. Effects of 6-diazo-5-oxo-L-norleucine and low glutamine on the synthesis of heparan sulfate proteoglycan by human colon carcinoma cells. J Biol Chem. 1987 Aug 15; 262(23):11188-99.
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Clark CC, Richards CF, Pacifici M, Iozzo RV. The effects of 6-diazo-5-oxo-L-norleucine, a glutamine analogue, on the structure of the major cartilage proteoglycan synthesized by cultured chondrocytes. J Biol Chem. 1987 Jul 25; 262(21):10229-38.