"Gossypol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Descriptor ID |
D006072
|
| MeSH Number(s) |
D02.455.849.765.444
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Gossypol".
Below are MeSH descriptors whose meaning is more specific than "Gossypol".
This graph shows the total number of publications written about "Gossypol" by people in this website by year, and whether "Gossypol" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gossypol" by people in Profiles.
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Jin M, Cheng Y, Guo X, Li M, Chakrabarty S, Liu K, Wu K, Xiao Y. Down-regulation of lysosomal protein ABCB6 increases gossypol susceptibility in Helicoverpa armigera. Insect Biochem Mol Biol. 2020 07; 122:103387.
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Baggstrom MQ, Qi Y, Koczywas M, Argiris A, Johnson EA, Millward MJ, Murphy SC, Erlichman C, Rudin CM, Govindan R. A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer. J Thorac Oncol. 2011 Oct; 6(10):1757-60.
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Liu G, Kelly WK, Wilding G, Leopold L, Brill K, Somer B. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin Cancer Res. 2009 May 01; 15(9):3172-6.