"Hemoglobin A2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia.
| Descriptor ID |
D006443
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| MeSH Number(s) |
D12.776.124.400.405.450 D12.776.422.316.762.380.450
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hemoglobin A2".
Below are MeSH descriptors whose meaning is more specific than "Hemoglobin A2".
This graph shows the total number of publications written about "Hemoglobin A2" by people in this website by year, and whether "Hemoglobin A2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
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Below are the most recent publications written about "Hemoglobin A2" by people in Profiles.
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Trifillis P, Adachi K, Yamaguchi T, Schwartz E, Surrey S. Expression studies of delta-globin gene alleles associated with reduced hemoglobin A2 levels in Greek Cypriots. J Biol Chem. 1996 Oct 25; 271(43):26931-8.
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Adachi K, Pang J, Reddy LR, Bradley LE, Chen Q, Trifillis P, Schwartz E, Surrey S. Polymerization of three hemoglobin A2 variants containing Val6 and inhibition of hemoglobin S polymerization by hemoglobin A2. J Biol Chem. 1996 Oct 04; 271(40):24557-63.
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Trifillis P, Ioannou P, Schwartz E, Surrey S. Identification of four novel delta-globin gene mutations in Greek Cypriots using polymerase chain reaction and automated fluorescence-based DNA sequence analysis. Blood. 1991 Dec 15; 78(12):3298-305.
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Fortina P, Delgrosso K, Werner E, Haines K, Rappaport E, Schwartz E, Surrey S. A greater than 200 kb deletion removing the entire beta-like globin gene cluster in a family of Irish descent. Hemoglobin. 1991; 15(1-2):23-41.
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GABUZDA TG, NATHAN DG, GARDNER FH. THALASSEMIA TRAIT. GENETIC COMBINATIONS OF INCREASED FETAL AND A2 HEMOGLOBINS. N Engl J Med. 1964 Jun 04; 270:1212-7.