Hydroxymethylglutaryl-CoA Synthase
"Hydroxymethylglutaryl-CoA Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.
| Descriptor ID |
D006904
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| MeSH Number(s) |
D08.811.913.050.612
|
| Concept/Terms |
Hydroxymethylglutaryl-CoA Synthase- Hydroxymethylglutaryl-CoA Synthase
- Hydroxymethylglutaryl CoA Synthase
- Synthase, Hydroxymethylglutaryl-CoA
- 3-hydroxy-3-methylglutaryl-coenzyme A synthase
- HMG-CoA synthase
|
Below are MeSH descriptors whose meaning is more general than "Hydroxymethylglutaryl-CoA Synthase".
Below are MeSH descriptors whose meaning is more specific than "Hydroxymethylglutaryl-CoA Synthase".
This graph shows the total number of publications written about "Hydroxymethylglutaryl-CoA Synthase" by people in this website by year, and whether "Hydroxymethylglutaryl-CoA Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hydroxymethylglutaryl-CoA Synthase" by people in Profiles.
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Gulette GA, Hass DT, Pandey K, Zhang Q, Han JYS, Engel A, Chao JR, Philp NJ, Hurley JB, Miller JML. Reassessing retinal pigment epithelial ketogenesis: Enzymatic assays for ketone body levels provide inaccurate results. Exp Eye Res. 2024 08; 245:109966.
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Shukla SK, Liu W, Sikder K, Addya S, Sarkar A, Wei Y, Rafiq K. HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. Sci Rep. 2017 07 04; 7(1):4590.
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Adijanto J, Du J, Moffat C, Seifert EL, Hurle JB, Philp NJ. The retinal pigment epithelium utilizes fatty acids for ketogenesis. J Biol Chem. 2014 Jul 25; 289(30):20570-82.
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Crooks DR, Natarajan TG, Jeong SY, Chen C, Park SY, Huang H, Ghosh MC, Tong WH, Haller RG, Wu C, Rouault TA. Elevated FGF21 secretion, PGC-1a and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. Hum Mol Genet. 2014 Jan 01; 23(1):24-39.
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Bahnson BJ. An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl-CoA synthase. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16399-400.
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Rokosz LL, Boulton DA, Butkiewicz EA, Sanyal G, Cueto MA, Lachance PA, Hermes JD. Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes. Arch Biochem Biophys. 1994 Jul; 312(1):1-13.