"Methyl Methanesulfonate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA.
| Descriptor ID |
D008741
|
| MeSH Number(s) |
D02.455.326.146.100.050.500.500 D02.886.645.600.055.050.510.500
|
| Concept/Terms |
Methyl Methanesulfonate- Methyl Methanesulfonate
- Methanesulfonate, Methyl
- Methyl Methylenesulfonate
- Methylmesilate
- Methylmethane Sulfonate
- Mesilate, Methyl
- Methyl Mesilate
- Methyl Mesylate
- Mesylate, Methyl
|
Below are MeSH descriptors whose meaning is more general than "Methyl Methanesulfonate".
Below are MeSH descriptors whose meaning is more specific than "Methyl Methanesulfonate".
This graph shows the total number of publications written about "Methyl Methanesulfonate" by people in this website by year, and whether "Methyl Methanesulfonate" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Methyl Methanesulfonate" by people in Profiles.
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Bonilla B, Brown AJ, Hengel SR, Rapchak KS, Mitchell D, Pressimone CA, Fagunloye AA, Luong TT, Russell RA, Vyas RK, Mertz TM, Zaher HS, Mosammaparast N, Malc EP, Mieczkowski PA, Roberts SA, Bernstein KA. The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions. Elife. 2021 11 01; 10.
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Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA. Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell. 2012 May 25; 46(4):424-35.
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Sevignani C, Cranston A, Iozzo RV, Fishel R, Calabretta B. Spontaneous and mutagen-induced transformation of primary cultures of Msh2-/- p53-/- colonocytes. Cancer Res. 1999 Dec 01; 59(23):5882-6.
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Mizumoto K, Glascott PA, Farber JL. Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate. Biochem Pharmacol. 1993 Nov 17; 46(10):1811-8.
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Herzog J, Farber JL. Inhibition of rat liver RNA polymerases by action of the methylating agents dimethylnitrosamine in vivo and methyl methanesulfonate in vitro. Cancer Res. 1976 May; 36(5):1761-70.