DNA Breaks, Double-Stranded
"DNA Breaks, Double-Stranded" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.
| Descriptor ID |
D053903
|
| MeSH Number(s) |
G05.200.210.220
|
| Concept/Terms |
DNA Breaks, Double-Stranded- DNA Breaks, Double-Stranded
- Break, Double-Stranded DNA
- Breaks, Double-Stranded DNA
- DNA Break, Double-Stranded
- DNA Breaks, Double Stranded
- Double-Stranded DNA Break
- Double Stranded DNA Break
- Double-Strand DNA Breaks
- Break, Double-Strand DNA
- Breaks, Double-Strand DNA
- DNA Break, Double-Strand
- DNA Breaks, Double-Strand
- Double Strand DNA Breaks
- Double-Strand DNA Break
- Double-Stranded DNA Breaks
- Double Stranded DNA Breaks
|
Below are MeSH descriptors whose meaning is more general than "DNA Breaks, Double-Stranded".
Below are MeSH descriptors whose meaning is more specific than "DNA Breaks, Double-Stranded".
This graph shows the total number of publications written about "DNA Breaks, Double-Stranded" by people in this website by year, and whether "DNA Breaks, Double-Stranded" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2007 | 4 | 1 | 5 |
| 2008 | 5 | 2 | 7 |
| 2009 | 4 | 2 | 6 |
| 2010 | 3 | 3 | 6 |
| 2011 | 5 | 0 | 5 |
| 2012 | 7 | 2 | 9 |
| 2013 | 8 | 5 | 13 |
| 2014 | 2 | 2 | 4 |
| 2015 | 5 | 6 | 11 |
| 2016 | 4 | 2 | 6 |
| 2017 | 3 | 3 | 6 |
| 2018 | 5 | 3 | 8 |
| 2019 | 5 | 4 | 9 |
| 2020 | 3 | 4 | 7 |
| 2021 | 3 | 6 | 9 |
| 2022 | 8 | 1 | 9 |
| 2023 | 1 | 2 | 3 |
| 2024 | 3 | 1 | 4 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Breaks, Double-Stranded" by people in Profiles.
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Soni A, Beisser D, Mladenov E, H?ller M, Wohlers I, Nikolov V, Magin S, Mussfeldt T, Klein-Hitpass L, Cornforth MN, Loucas BD, Rahmann S, Iliakis G. NGS Detects Extensive Genomic Alterations in Survivors of Irradiated Normal Human Fibroblast Cells. Radiat Res. 2025 01 01; 203(1):37-52.
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Lin X, Soni A, Hessenow R, Sun Y, Mladenov E, Guberina M, Stuschke M, Iliakis G. Talazoparib enhances resection at DSBs and renders HR-proficient cancer cells susceptible to Pol? inhibition. Radiother Oncol. 2024 11; 200:110475.
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Vekariya U, Minakhin L, Chandramouly G, Tyagi M, Kent T, Sullivan-Reed K, Atkins J, Ralph D, Nieborowska-Skorska M, Kukuyan AM, Tang HY, Pomerantz RT, Skorski T. PARG is essential for Pol?-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Nat Commun. 2024 07 11; 15(1):5822.
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Yu C, Asadian S, Tigano M. Molecular and cellular consequences of mitochondrial DNA double-stranded breaks. Hum Mol Genet. 2024 05 22; 33(R1):R12-R18.
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Nikjoo H, Rahmanian S, Taleei R. Modelling DNA damage-repair and beyond. Prog Biophys Mol Biol. 2024 08; 190:1-18.
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Mladenov E, Mladenova V, Stuschke M, Iliakis G. New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement. Int J Mol Sci. 2023 Oct 06; 24(19).
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Haberland VMM, Magin S, Iliakis G, Hartwig A. Impact of Manganese and Chromate on Specific DNA Double-Strand Break Repair Pathways. Int J Mol Sci. 2023 Jun 20; 24(12).
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Li F, Mladenov E, Sun Y, Soni A, Stuschke M, Timmermann B, Iliakis G. Low CDK Activity and Enhanced Degradation by APC/CCDH1 Abolishes CtIP Activity and Alt-EJ in Quiescent Cells. Cells. 2023 06 01; 12(11).
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Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT. Pol? promotes microhomology-mediated end-joining. Nat Struct Mol Biol. 2023 01; 30(1):107-114.
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Pei X, Mladenov E, Soni A, Li F, Stuschke M, Iliakis G. PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination. Int J Mol Sci. 2022 Oct 25; 23(21).