Philadelphia Chromosome

"Philadelphia Chromosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).

Descriptor ID	D010677
MeSH Number(s)	A11.284.187.520.300.325.345.500 A11.284.187.520.300.505.515.500 C23.550.210.870.680 G05.360.162.520.300.325.345.700 G05.360.162.520.300.505.515.700 G05.365.590.175.870.680
Concept/Terms	Philadelphia Chromosome Philadelphia Chromosome Chromosome, Philadelphia Ph 1 Chromosome 1 Chromosomes, Ph Chromosome, Ph 1 Chromosomes, Ph 1 Ph 1 Chromosomes Ph1 Chromosome Chromosome, Ph1 Chromosomes, Ph1 Ph1 Chromosomes

Below are MeSH descriptors whose meaning is more general than "Philadelphia Chromosome".

Anatomy [A]
Cells [A11]
Cellular Structures [A11.284]
Chromosomes [A11.284.187]
Chromosomes, Mammalian [A11.284.187.520]
Chromosomes, Human [A11.284.187.520.300]
Chromosomes, Human, 6-12 and X [A11.284.187.520.300.325]
Chromosomes, Human, Pair 9 [A11.284.187.520.300.325.345]
Philadelphia Chromosome [A11.284.187.520.300.325.345.500]
Chromosomes, Human, 21-22 and Y [A11.284.187.520.300.505]
Chromosomes, Human, Pair 22 [A11.284.187.520.300.505.515]
Philadelphia Chromosome [A11.284.187.520.300.505.515.500]
Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Chromosome Aberrations [C23.550.210]
Translocation, Genetic [C23.550.210.870]
Philadelphia Chromosome [C23.550.210.870.680]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Chromosomes [G05.360.162]
Chromosomes, Mammalian [G05.360.162.520]
Chromosomes, Human [G05.360.162.520.300]
Chromosomes, Human, 6-12 and X [G05.360.162.520.300.325]
Chromosomes, Human, Pair 9 [G05.360.162.520.300.325.345]
Philadelphia Chromosome [G05.360.162.520.300.325.345.700]
Chromosomes, Human, 21-22 and Y [G05.360.162.520.300.505]
Chromosomes, Human, Pair 22 [G05.360.162.520.300.505.515]
Philadelphia Chromosome [G05.360.162.520.300.505.515.700]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Chromosome Aberrations [G05.365.590.175]
Translocation, Genetic [G05.365.590.175.870]
Philadelphia Chromosome [G05.365.590.175.870.680]

Below are MeSH descriptors whose meaning is related to "Philadelphia Chromosome".

Below are MeSH descriptors whose meaning is more specific than "Philadelphia Chromosome".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Philadelphia Chromosome" by people in this website by year, and whether "Philadelphia Chromosome" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 1997 and 2011 and 2012 and 2016 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
2011	0	1	1
2012	0	1	1
2016	0	1	1
2024	0	1	1

Below are the most recent publications written about "Philadelphia Chromosome" by people in Profiles.

Shah NP, Bhatia R, Altman JK, Amaya M, Begna KH, Berman E, Chan O, Clements J, Collins RH, Curtin PT, DeAngelo DJ, Drazer M, Maness L, Metheny L, Mohan S, Moore JO, Oehler V, Pratz K, Pusic I, Rose MG, Shomali W, Smith BD, Styler M, Talpaz M, Tanaka TN, Tantravahi S, Thompson J, Tsai S, Vaughn J, Welborn J, Yang DT, Sundar H, Gregory K. Chronic Myeloid Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2024 02; 22(1):43-69.

View in: PubMed
Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, Choi JK, Tong W. LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest. 2016 Apr 01; 126(4):1267-81.

View in: PubMed
Alvarnas JC, Brown PA, Aoun P, Ballen KK, Bellam N, Blum W, Boyer MW, Carraway HE, Coccia PF, Coutre SE, Cultrera J, Damon LE, DeAngelo DJ, Douer D, Frangoul H, Frankfurt O, Goorha S, Millenson MM, O'Brien S, Petersdorf SH, Rao AV, Terezakis S, Uy G, Wetzler M, Zelenetz AD, Naganuma M, Gregory KM. Acute lymphoblastic leukemia. J Natl Compr Canc Netw. 2012 Jul 01; 10(7):858-914.

View in: PubMed
Sbenghe MM, Florea AD, Mather P, Gitelson E. Chronic myeloid leukemia following heart transplantation and immunosuppression with tacrolimus. Clin Adv Hematol Oncol. 2011 Aug; 9(8):623-7.

View in: PubMed
Skorski T, Nieborowska-Skorska M, Wlodarski P, Perrotti D, Hoser G, Kawiak J, Majewski M, Christensen L, Iozzo RV, Calabretta B. Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides. J Natl Cancer Inst. 1997 Jan 15; 89(2):124-33.

View in: PubMed

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