"Poly I-C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.
| Descriptor ID |
D011070
|
| MeSH Number(s) |
D13.695.578.550.560.600 D13.695.578.550.650.600
|
| Concept/Terms |
Poly I-C- Poly I-C
- Poly I C
- Poly(I-C)
- Polyriboinosinic-Polyribocytidylic Acid
- Polyriboinosinic Polyribocytidylic Acid
- Polyribose Inosin-Cytidil
- Inosin-Cytidil, Polyribose
- Polyribose Inosin Cytidil
- Poly(rI).Poly(rC)
- Polyinosinic-Polycytidylic Acid
- Polyinosinic Polycytidylic Acid
- Polyinosinic-Polycytidylic Acid (High MW)
|
Below are MeSH descriptors whose meaning is more general than "Poly I-C".
Below are MeSH descriptors whose meaning is more specific than "Poly I-C".
This graph shows the total number of publications written about "Poly I-C" by people in this website by year, and whether "Poly I-C" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Poly I-C" by people in Profiles.
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Musumeci G, Castrogiovanni P, Barbagallo I, Tibullo D, Sanfilippo C, Nunnari G, Pellican? GF, Pavone P, Caltabiano R, Di Marco R, Imbesi R, Di Rosa M. Expression of the OAS Gene Family Is Highly Modulated in Subjects Affected by Juvenile Dermatomyositis, Resembling an Immune Response to a dsRNA Virus Infection. Int J Mol Sci. 2018 Sep 17; 19(9).
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Volk DW, Chitrapu A, Edelson JR, Roman KM, Moroco AE, Lewis DA. Molecular mechanisms and timing of cortical immune activation in schizophrenia. Am J Psychiatry. 2015 Nov 01; 172(11):1112-21.
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Mitchell WM, Nicodemus CF, Carter WA, Horvath JC, Strayer DR. Discordant biological and toxicological species responses to TLR3 activation. Am J Pathol. 2014 Apr; 184(4):1062-1072.
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Touil T, Fitzgerald D, Zhang GX, Rostami A, Gran B. Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. J Immunol. 2006 Dec 01; 177(11):7505-9.
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Gillespie D, Hubbell HR, Carter WA, Midgette P, Elsasser W, Mullaney R, Strayer DR. Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements. In Vivo. 1994 May-Jun; 8(3):375-81.
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Gaspari AA, Fleisher TA, Kraemer KH. Impaired interferon production and natural killer cell activation in patients with the skin cancer-prone disorder, xeroderma pigmentosum. J Clin Invest. 1993 Sep; 92(3):1135-42.
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Keller R, Keist R, Van der Meide PH, Groscurth P, Aguet M, Leist TP. Induction, maintenance, and reinduction of tumoricidal activity in bone marrow-derived mononuclear phagocytes by Corynebacterium parvum. Evidence for the involvement of a T cell- and interferon-gamma-independent pathway of macrophage activation. J Immunol. 1987 Apr 01; 138(7):2366-71.
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De Clercq E, Huang GF, Bhooshan B, Ledley G, Torrence PF. Interferon induction by mismatched analogues of polyinosinic acid . polycytidylic acid [(Ix,U)n.(C)n]. Nucleic Acids Res. 1979 Dec 11; 7(7):2003-14.