Receptors, GABA-A

"Receptors, GABA-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.

Descriptor ID	D011963
MeSH Number(s)	D12.776.157.530.400.175.562 D12.776.157.530.400.400.100.100 D12.776.543.550.450.175.562 D12.776.543.550.450.500.100.100 D12.776.543.585.400.175.562 D12.776.543.585.400.500.100.100 D12.776.543.750.130.500 D12.776.543.750.720.200.300.300
Concept/Terms	Receptors, GABA-A Receptors, GABA-A Receptors, GABA A GABA-A Receptor GABA A Receptor Receptor, GABA-A GABA-A Receptors GABA A Receptors gamma-Aminobutyric Acid Subtype A Receptors gamma Aminobutyric Acid Subtype A Receptors Muscimol Receptor Receptor, Muscimol Receptors, Benzodiazepine-GABA Receptors, Benzodiazepine GABA Receptors, Muscimol Benzodiazepine-GABA Receptor Benzodiazepine GABA Receptor Receptor, Benzodiazepine-GABA GABA-Benzodiazepine Receptor GABA Benzodiazepine Receptor Receptor, GABA-Benzodiazepine GABA-Benzodiazepine Receptors GABA Benzodiazepine Receptors Benzodiazepine-Gaba Receptors Benzodiazepine Gaba Receptors Receptors, GABA-Benzodiazepine Receptors, GABA Benzodiazepine GABA(A) Receptor Muscimol Receptors GABA-A Receptor alpha Subunit GABA-A Receptor alpha Subunit GABA A Receptor alpha Subunit GABA-A Receptor rho Subunit GABA-A Receptor rho Subunit GABA A Receptor rho Subunit GABA-A Receptor delta Subunit GABA-A Receptor delta Subunit GABA A Receptor delta Subunit delta Subunit, GABA-A Receptor delta Subunit, GABA A Receptor GABA-A Receptor epsilon Subunit GABA-A Receptor epsilon Subunit GABA A Receptor epsilon Subunit epsilon Subunit, GABA-A Receptor epsilon Subunit, GABA A Receptor GABA-A Receptor gamma Subunit GABA-A Receptor gamma Subunit GABA A Receptor gamma Subunit Benzodiazepine Receptor Benzodiazepine Receptor Receptor, Benzodiazepine Receptors, Diazepam Diazepam Receptor Receptor, Diazepam Diazepam Receptors Benzodiazepine Receptors Receptors, Benzodiazepine GABA-A Receptor beta Subunit GABA-A Receptor beta Subunit GABA A Receptor beta Subunit

Below are MeSH descriptors whose meaning is more general than "Receptors, GABA-A".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Chloride Channels [D12.776.157.530.400.175]
Receptors, GABA-A [D12.776.157.530.400.175.562]
Ligand-Gated Ion Channels [D12.776.157.530.400.400]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
Receptors, GABA-A [D12.776.157.530.400.400.100.100]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Chloride Channels [D12.776.543.550.450.175]
Receptors, GABA-A [D12.776.543.550.450.175.562]
Ligand-Gated Ion Channels [D12.776.543.550.450.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
Receptors, GABA-A [D12.776.543.550.450.500.100.100]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Chloride Channels [D12.776.543.585.400.175]
Receptors, GABA-A [D12.776.543.585.400.175.562]
Ligand-Gated Ion Channels [D12.776.543.585.400.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
Receptors, GABA-A [D12.776.543.585.400.500.100.100]
Receptors, Cell Surface [D12.776.543.750]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.130]
Receptors, GABA-A [D12.776.543.750.130.500]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Amino Acid [D12.776.543.750.720.200]
Receptors, GABA [D12.776.543.750.720.200.300]
Receptors, GABA-A [D12.776.543.750.720.200.300.300]

Below are MeSH descriptors whose meaning is related to "Receptors, GABA-A".

Below are MeSH descriptors whose meaning is more specific than "Receptors, GABA-A".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, GABA-A" by people in this website by year, and whether "Receptors, GABA-A" was a major or minor topic of these publications.

Bar chart showing 15 publications over 11 distinct years, with a maximum of 3 publications in 1999

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
1999	0	3	3
2000	0	1	1
2001	2	0	2
2003	1	0	1
2005	0	1	1
2008	1	0	1
2009	1	0	1
2013	1	0	1
2017	2	0	2
2024	0	1	1

Below are the most recent publications written about "Receptors, GABA-A" by people in Profiles.

Philip AB, Brohan J, Goudra B. The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review. CNS Drugs. 2025 01; 39(1):39-54.

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Lorenz-Guertin JM, Wilcox MR, Zhang M, Larsen MB, Pilli J, Schmidt BF, Bruchez MP, Johnson JW, Waggoner AS, Watkins SC, Jacob TC. A versatile optical tool for studying synaptic GABAA receptor trafficking. J Cell Sci. 2017 Nov 15; 130(22):3933-3945.

View in: PubMed
M?ller RS, Wuttke TV, Helbig I, Marini C, Johannesen KM, Brilstra EH, Vaher U, Borggraefe I, Talvik I, Talvik T, Kluger G, Francois LL, Lesca G, de Bellescize J, Blichfeldt S, Chatron N, Holert N, Jacobs J, Swinkels M, Betzler C, Syrbe S, Nikanorova M, Myers CT, Larsen LH, Vejzovic S, Pendziwiat M, von Spiczak S, Hopkins S, Dubbs H, Mang Y, Mukhin K, Holthausen H, van Gassen KL, Dahl HA, Tommerup N, Mefford HC, Rubboli G, Guerrini R, Lemke JR, Lerche H, Muhle H, Maljevic S. Mutations in GABRB3: From febrile seizures to epileptic encephalopathies. Neurology. 2017 01 31; 88(5):483-492.

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Chugani HT, Kumar A, Muzik O. GABA(A) receptor imaging with positron emission tomography in the human newborn: a unique binding pattern. Pediatr Neurol. 2013 Jun; 48(6):459-62.

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Kumar A, Muzik O, Chugani D, Chakraborty P, Chugani HT. PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults. J Nucl Med. 2010 Jan; 51(1):139-44.

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Juh?sz C, Asano E, Shah A, Chugani DC, Batista CE, Muzik O, Sood S, Chugani HT. Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate? Epilepsia. 2009 Feb; 50(2):240-50.

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Sundaram SK, Chugani HT, Chugani DC. Positron emission tomography methods with potential for increased understanding of mental retardation and developmental disabilities. Ment Retard Dev Disabil Res Rev. 2005; 11(4):325-30.

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Hagiwara N, Katarova Z, Siracusa LD, Brilliant MH. Nonneuronal expression of the GABA(A) beta3 subunit gene is required for normal palate development in mice. Dev Biol. 2003 Feb 01; 254(1):93-101.

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Juh?sz C, Muzik O, Chugani DC, Shen C, Janisse J, Chugani HT. Prolonged vigabatrin treatment modifies developmental changes of GABA(A)-receptor binding in young children with epilepsy. Epilepsia. 2001 Oct; 42(10):1320-6.

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Chugani DC, Muzik O, Juh?sz C, Janisse JJ, Ager J, Chugani HT. Postnatal maturation of human GABAA receptors measured with positron emission tomography. Ann Neurol. 2001 May; 49(5):618-26.

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