"Bestrophins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
| Descriptor ID |
D000075002
|
| MeSH Number(s) |
D12.776.157.530.400.175.063 D12.776.306.228 D12.776.543.550.450.175.063 D12.776.543.585.400.175.063
|
| Concept/Terms |
Bestrophins- Bestrophins
- Bestrophin Proteins
- Bestrophin Family
Bestrophin-1- Bestrophin-1
- Bestrophin 1
- BEST-1 Protein
- BEST 1 Protein
Bestrophin-2- Bestrophin-2
- Bestrophin 2
- BEST-2 Protein
- BEST 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Bestrophins".
Below are MeSH descriptors whose meaning is more specific than "Bestrophins".
This graph shows the total number of publications written about "Bestrophins" by people in this website by year, and whether "Bestrophins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bestrophins" by people in Profiles.
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Mano F, Pfannkoch C, LoBue SA, Olsen TW, Marmorstein AD, Pulido JS. Response to Weisschuh's "Comment: a novel missense mutation in BEST1 associated with an autosomal-dominant vitreoretinochoroidopathy (ADVIRC) phenotype". Ophthalmic Genet. 2019 02; 40(1):88-89.
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Mano F, LoBue SA, Olsen TW, Marmorstein AD, Pulido JS. A novel missense mutation in BEST1 associated with an autosomal-dominant vitreoretinochoroidopathy (ADVIRC) phenotype. Ophthalmic Genet. 2018 12; 39(6):749-753.
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Johnson AA, Guziewicz KE, Lee CJ, Kalathur RC, Pulido JS, Marmorstein LY, Marmorstein AD. Bestrophin 1 and retinal disease. Prog Retin Eye Res. 2017 05; 58:45-69.
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Johnson AA, Bachman LA, Gilles BJ, Cross SD, Stelzig KE, Resch ZT, Marmorstein LY, Pulido JS, Marmorstein AD. Autosomal Recessive Bestrophinopathy Is Not Associated With the Loss of Bestrophin-1 Anion Channel Function in a Patient With a Novel BEST1 Mutation. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4619-30.