"Substantia Nigra" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.
| Descriptor ID |
D013378
|
| MeSH Number(s) |
A08.186.211.132.659.413.656
|
| Concept/Terms |
Substantia Nigra- Substantia Nigra
- Nigra, Substantia
- Nigras, Substantia
- Substantia Nigras
|
Below are MeSH descriptors whose meaning is more general than "Substantia Nigra".
Below are MeSH descriptors whose meaning is more specific than "Substantia Nigra".
This graph shows the total number of publications written about "Substantia Nigra" by people in this website by year, and whether "Substantia Nigra" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 2 | 1 | 3 |
| 2003 | 3 | 1 | 4 |
| 2005 | 1 | 2 | 3 |
| 2006 | 1 | 2 | 3 |
| 2007 | 1 | 2 | 3 |
| 2008 | 3 | 0 | 3 |
| 2009 | 2 | 2 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 2 | 1 | 3 |
| 2012 | 2 | 3 | 5 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Substantia Nigra" by people in Profiles.
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Jiang C, Li Y, Duan K, Zhan T, Chen Z, Wang Y, Zhao R, Ma C, Guo Y, Liu C. [Parkin deletion affects PINK1/Parkin-mediated mitochondrial autophagy to exacerbate neuroinflammation and accelerate progression of Parkinson's disease in mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Dec 20; 44(12):2359-2366.
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Smit RD, Ghosh B, Campion TJ, Stingel R, Lavell E, Hooper R, Fan X, Soboloff J, Smith GM. STAT3 protects dopaminergic neurons against degeneration in animal model of Parkinson's disease. Brain Res. 2024 02 01; 1824:148691.
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Schneider JS, Singh G, Williams CK, Singh V. GM1 ganglioside modifies microglial and neuroinflammatory responses to a-synuclein in the rat AAV-A53T a-synuclein model of Parkinson's disease. Mol Cell Neurosci. 2022 05; 120:103729.
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Rocha SM, Bantle CM, Aboellail T, Chatterjee D, Smeyne RJ, Tjalkens RB. Rotenone induces regionally distinct a-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice. Neurobiol Dis. 2022 06 01; 167:105685.
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Gupta RK. Editorial for "Serum Ceruloplasmin Depletion is Associated With the Widespread Accumulation of Brain Iron in Parkinson's Disease". J Magn Reson Imaging. 2021 10; 54(4):1107.
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Oakes HV, McWethy D, Ketchem S, Tran L, Phillips K, Oakley L, Smeyne RJ, Pond BB. Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism. Neurotox Res. 2021 Jun; 39(3):667-676.
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Bantle CM, French CT, Cummings JE, Sadasivan S, Tran K, Slayden RA, Smeyne RJ, Tjalkens RB. Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus. PLoS One. 2021; 16(1):e0245171.
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Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA. Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin. Brain Struct Funct. 2019 Nov; 224(8):2983-2999.
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Schneider JS, Aras R, Williams CK, Koprich JB, Brotchie JM, Singh V. GM1 Ganglioside Modifies a-Synuclein Toxicity and is Neuroprotective in a Rat a-Synuclein Model of Parkinson's Disease. Sci Rep. 2019 06 10; 9(1):8362.
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Schneider JS. Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson's disease. PLoS One. 2018; 13(6):e0199189.