Heparin-binding EGF-like Growth Factor
"Heparin-binding EGF-like Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
| Descriptor ID |
D066257
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| MeSH Number(s) |
D12.644.276.382.625 D12.776.467.382.625 D23.529.382.625
|
| Concept/Terms |
Short Form HB-EGF- Short Form HB-EGF
- HB-EGF, Short Form
- Short Form HB EGF
- SF HB-EGF
- SF HB EGF
Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein- Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein
- Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein
- Receptor, Diphtheria Toxin
- HB-EGF Precursor
- HB EGF Precursor
- Diphtheria Toxin Receptor
- Toxin Receptor, Diphtheria
- Diphtheria Toxin Receptors
- Receptors, Diphtheria Toxin
- Toxin Receptors, Diphtheria
|
Below are MeSH descriptors whose meaning is more general than "Heparin-binding EGF-like Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Heparin-binding EGF-like Growth Factor".
This graph shows the total number of publications written about "Heparin-binding EGF-like Growth Factor" by people in this website by year, and whether "Heparin-binding EGF-like Growth Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Heparin-binding EGF-like Growth Factor" by people in Profiles.
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Shin S, Upadhyay N, Greenbaum LE, Kaestner KH. Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology. 2015 Jan; 148(1):192-202.e3.
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Leach RE, Jessmon P, Coutifaris C, Kruger M, Myers ER, Ali-Fehmi R, Carson SA, Legro RS, Schlaff WD, Carr BR, Steinkampf MP, Silva S, Leppert PC, Giudice L, Diamond MP, Armant DR. High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples. Hum Reprod. 2012 Mar; 27(3):814-28.
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Nagy N, Almaani N, Tanaka A, Lai-Cheong JE, Techanukul T, Mellerio JE, McGrath JA. HB-EGF induces COL7A1 expression in keratinocytes and fibroblasts: possible mechanism underlying allogeneic fibroblast therapy in recessive dystrophic epidermolysis Bullosa. J Invest Dermatol. 2011 Aug; 131(8):1771-4.
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Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ. Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res. 2011 Apr; 26(4):747-60.
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Bobr A, Olvera-Gomez I, Igyarto BZ, Haley KM, Hogquist KA, Kaplan DH. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol. 2010 Oct 15; 185(8):4724-8.
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Kivisaari AK, Kallajoki M, Ala-aho R, McGrath JA, Bauer JW, K?nigov? R, Medvecz M, Beckert W, Gr?nman R, K?h?ri VM. Matrix metalloproteinase-7 activates heparin-binding epidermal growth factor-like growth factor in cutaneous squamous cell carcinoma. Br J Dermatol. 2010 Oct; 163(4):726-35.
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Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S. G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem. 2005 Jul 15; 280(28):26592-9.