Epidermal Growth Factor

"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

Descriptor ID	D004815
MeSH Number(s)	D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
Concept/Terms	Epidermal Growth Factor Epidermal Growth Factor Growth Factor, Epidermal Urogastrone Epidermal Growth Factor-Urogastrone Growth Factor-Urogastrone, Epidermal Human Urinary Gastric Inhibitor beta-Urogastrone beta Urogastrone EGF

Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Gastrointestinal Hormones [D06.472.317]
Epidermal Growth Factor [D06.472.317.350]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Epidermal Growth Factor [D12.644.276.382.500]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Epidermal Growth Factor [D12.776.467.382.500]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Epidermal Growth Factor [D23.529.382.500]

Below are MeSH descriptors whose meaning is related to "Epidermal Growth Factor".

Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.

Bar chart showing 75 publications over 21 distinct years, with a maximum of 7 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	3	4
1998	2	0	2
1999	0	5	5
2000	0	5	5
2001	1	5	6
2002	2	4	6
2003	0	3	3
2004	0	2	2
2005	3	2	5
2006	1	6	7
2007	1	3	4
2008	0	3	3
2009	1	1	2
2010	2	3	5
2011	0	2	2
2012	1	2	3
2013	2	2	4
2014	1	1	2
2015	2	0	2
2017	0	2	2
2024	0	1	1

Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.

Shimonosono M, Morimoto M, Hirose W, Tomita Y, Matsuura N, Flashner S, Ebadi MS, Okayasu EH, Lee CY, Britton WR, Martin C, Wuertz BR, Parikh AS, Sachdeva UM, Ondrey FG, Atigadda VR, Elmets CA, Abrams JA, Muir AB, Klein-Szanto AJ, Weinberg KI, Momen-Heravi F, Nakagawa H. Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids. Biomolecules. 2024 09 05; 14(9).

View in: PubMed
He H, Kuriyan AE, Su CW, Mahabole M, Zhang Y, Zhu YT, Flynn HW, Parel JM, Tseng SC. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3. Sci Rep. 2017 03 02; 7:43736.

View in: PubMed
Said AH, Hu S, Abutaleb A, Watkins T, Cheng K, Chahdi A, Kuppusamy P, Saxena N, Xie G, Raufman JP. Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. Biochem J. 2017 02 20; 474(5):647-665.

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Vu HL, Rosenbaum S, Capparelli C, Purwin TJ, Davies MA, Berger AC, Aplin AE. MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma. J Invest Dermatol. 2016 Feb; 136(2):453-463.

View in: PubMed
Lee SJ, Li Z, Litan A, Yoo S, Langhans SA. EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation. BMC Cell Biol. 2015 Sep 18; 16:24.

View in: PubMed
Lee KM, Nam K, Oh S, Lim J, Kim YP, Lee JW, Yu JH, Ahn SH, Kim SB, Noh DY, Lee T, Shin I. Extracellular matrix protein 1 regulates cell proliferation and trastuzumab resistance through activation of epidermal growth factor signaling. Breast Cancer Res. 2014 Dec 11; 16(6):479.

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Wolle D, Lee SJ, Li Z, Litan A, Barwe SP, Langhans SA. Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma. Cancer Med. 2014 Oct; 3(5):1146-58.

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Lahoti TS, Hughes JM, Kusnadi A, John K, Zhu B, Murray IA, Gowda K, Peters JM, Amin SG, Perdew GH. Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb; 348(2):236-45.

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Wu W, Kong Z, Duan X, Zhu H, Li S, Zeng S, Liang Y, Iliakis G, Gui Z, Yang D. Inhibition of PARP1 by small interfering RNA enhances docetaxel activity against human prostate cancer PC3 cells. Biochem Biophys Res Commun. 2013 Dec 06; 442(1-2):127-32.

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So CH, Michal A, Komolov KE, Luo J, Benovic JL. G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation. Mol Biol Cell. 2013 Sep; 24(18):2795-806.

View in: PubMed

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