"rhoC GTP-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A rho GTP-binding protein that is prenylated (see PROTEIN PRENYLATION) at its C-terminus and cycles between the cytoplasm and plasma membrane, linking receptor signaling pathways with assembly of FOCAL ADHESIONS; STRESS FIBERS; and contractile ring formation during CYTOKINESIS. It is overexpressed in proliferating and metastatic tumor cells.
| Descriptor ID |
D000075024
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.700.650 D12.644.360.525.700.650 D12.776.157.325.515.700.650 D12.776.476.525.700.650
|
| Concept/Terms |
rhoC GTP-Binding Protein- rhoC GTP-Binding Protein
- GTP-Binding Protein, rhoC
- rhoC GTP Binding Protein
- rhoC GTPase
- ras Homolog Family Member C
|
Below are MeSH descriptors whose meaning is more general than "rhoC GTP-Binding Protein".
Below are MeSH descriptors whose meaning is more specific than "rhoC GTP-Binding Protein".
This graph shows the total number of publications written about "rhoC GTP-Binding Protein" by people in this website by year, and whether "rhoC GTP-Binding Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 3 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "rhoC GTP-Binding Protein" by people in Profiles.
-
Lehman HL, Dashner EJ, Lucey M, Vermeulen P, Dirix L, Van Laere S, van Golen KL. Modeling and characterization of inflammatory breast cancer emboli grown in vitro. Int J Cancer. 2013 May 15; 132(10):2283-94.
-
Mills J, Oliver A, Sherwin JC, Frydenberg M, Peters JS, Costello A, Harewood L, Love C, Redgrave N, van Golen KL, Bailey M, Pedersen J. Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer. Pathology. 2012 Oct; 44(6):513-8.
-
Lehman HL, Van Laere SJ, van Golen CM, Vermeulen PB, Dirix LY, van Golen KL. Regulation of inflammatory breast cancer cell invasion through Akt1/PKBa phosphorylation of RhoC GTPase. Mol Cancer Res. 2012 Oct; 10(10):1306-18.
-
Chatterjee M, van Golen KL. Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype. Int J Cancer. 2011 Jul 01; 129(1):61-9.
-
Lucey M, Unger H, van Golen KL. RhoC GTPase activation assay. J Vis Exp. 2010 Aug 22; (42).
-
Yao H, Dashner EJ, van Golen CM, van Golen KL. RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility. Oncogene. 2006 Apr 13; 25(16):2285-96.
-
Van den Eynden GG, Van Laere SJ, Van der Auwera I, Merajver SD, Van Marck EA, van Dam P, Vermeulen PB, Dirix LY, van Golen KL. Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer. Breast Cancer Res Treat. 2006 Feb; 95(3):219-28.
-
Kleer CG, Griffith KA, Sabel MS, Gallagher G, van Golen KL, Wu ZF, Merajver SD. RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast. Breast Cancer Res Treat. 2005 Sep; 93(2):101-10.
-
Lin M, DiVito MM, Merajver SD, Boyanapalli M, van Golen KL. Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1. Mol Cancer. 2005 Jun 21; 4(1):21.
-
van Golen KL, Bao L, DiVito MM, Wu Z, Prendergast GC, Merajver SD. Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor. Mol Cancer Ther. 2002 Jun; 1(8):575-83.