Mutagenesis, Insertional

"Mutagenesis, Insertional" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

Descriptor ID	D016254
MeSH Number(s)	E05.393.420.601.550 G05.365.590.575 G05.558.550
Concept/Terms	Mutagenesis, Insertional Mutagenesis, Insertional Insertional Mutagenesis Sequence Insertion Sequence Insertion Insertion, Sequence Insertions, Sequence Sequence Insertions Viral Insertional Mutagenesis Viral Insertional Mutagenesis Insertional Mutagenesis, Viral Mutagenesis, Viral Insertional Linker-Insertion Mutagenesis Linker-Insertion Mutagenesis Linker Insertion Mutagenesis Mutagenesis, Linker-Insertion Gene Insertion Gene Insertion Gene Insertions Insertion, Gene Insertions, Gene Insertion Mutation Insertion Mutation Insertion Mutations Mutation, Insertion Mutations, Insertion Insertional Activation Insertional Activation Activation, Insertional Activations, Insertional Insertional Activations Mutagenesis, Cassette Mutagenesis, Cassette Cassette Mutagenesis

Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Insertional".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Protein Engineering [E05.393.420.601]
Mutagenesis, Insertional [E05.393.420.601.550]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Mutagenesis, Insertional [G05.365.590.575]
Mutagenesis [G05.558]
Mutagenesis, Insertional [G05.558.550]

Below are MeSH descriptors whose meaning is related to "Mutagenesis, Insertional".

Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Insertional".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mutagenesis, Insertional" by people in this website by year, and whether "Mutagenesis, Insertional" was a major or minor topic of these publications.

Bar chart showing 21 publications over 15 distinct years, with a maximum of 3 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	2	3
1997	0	2	2
1998	0	2	2
2002	1	0	1
2003	0	1	1
2004	0	1	1
2005	0	1	1
2006	0	1	1
2008	1	0	1
2009	1	1	2
2010	0	1	1
2011	0	2	2
2013	0	1	1
2017	1	0	1
2019	0	1	1

Below are the most recent publications written about "Mutagenesis, Insertional" by people in Profiles.

Tarnauskaite ?, Bicknell LS, Marsh JA, Murray JE, Parry DA, Logan CV, Bober MB, de Silva DC, Duker AL, Sillence D, Wise C, Jackson AP, Murina O, Reijns MAM. Biallelic variants in DNA2 cause microcephalic primordial dwarfism. Hum Mutat. 2019 08; 40(8):1063-1070.

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Mesarich CH, Rees-George J, Gardner PP, Ghomi FA, Gerth ML, Andersen MT, Rikkerink EH, Fineran PC, Templeton MD. Transposon insertion libraries for the characterization of mutants from the kiwifruit pathogen Pseudomonas syringae pv. actinidiae. PLoS One. 2017; 12(3):e0172790.

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Treff NR, Fedick A, Tao X, Devkota B, Taylor D, Scott RT. Evaluation of targeted next-generation sequencing-based preimplantation genetic diagnosis of?monogenic disease. Fertil Steril. 2013 Apr; 99(5):1377-1384.e6.

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Liu C, Sanders JM, Pascal JM, Hou YM. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases. RNA. 2012 Feb; 18(2):213-21.

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Lai-Cheong JE, Moss C, Parsons M, Almaani N, McGrath JA. Revertant mosaicism in Kindler syndrome. J Invest Dermatol. 2012 Mar; 132(3 Pt 1):730-2.

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Lohr NJ, Molleston JP, Strauss KA, Torres-Martinez W, Sherman EA, Squires RH, Rider NL, Chikwava KR, Cummings OW, Morton DH, Puffenberger EG. Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. Am J Hum Genet. 2010 Mar 12; 86(3):447-53.

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Bhardwaj A, Walker-Kopp N, Casjens SR, Cingolani G. An evolutionarily conserved family of virion tail needles related to bacteriophage P22 gp26: correlation between structural stability and length of the alpha-helical trimeric coiled coil. J Mol Biol. 2009 Aug 07; 391(1):227-45.

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Jordan PS, Poon A, Eron J, Squires K, Ignacio C, Richman DD, Smith DM. A novel codon insert in protease of clade B HIV type 1. AIDS Res Hum Retroviruses. 2009 May; 25(5):547-50.

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Lasota J, Kuban W, Wardelmann E, Debiec-Rychter M, Merkelbach-Bruse S, Sciot R, Rys J, Steigen SE, Iwanik K, Holden JA, Jerzak Vel Dobosz A, Schildhaus HU, Miettinen M. KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants. Hum Pathol. 2008 Dec; 39(12):1728-36.

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Strayer DS, Agrawal L, Cordelier P, Liu B, Louboutin JP, Marusich E, McKee HJ, Ren CN, Strayer MS. Long-term gene expression in dividing and nondividing cells using SV40-derived vectors. Mol Biotechnol. 2006 Oct; 34(2):257-70.

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