Transducin

"Transducin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.

Descriptor ID	D015293
MeSH Number(s)	D08.811.277.040.330.300.200.800 D12.644.360.360.940 D12.776.157.325.332.940 D12.776.476.375.940 D12.776.543.325.800
Concept/Terms	Transducin Transducin Transducin G-Protein (Gt) Gt, Transducin G-Protein G-Protein Gt, Transducin Gt, Transducin G Protein Transducin G-Protein Gt G-Protein, Inhibitory Gt G Protein, Inhibitory Gt Gt G-Protein, Inhibitory Inhibitory Gt G-Protein gamma-Transducin gamma-Transducin gamma Transducin Transducin, gamma Subunit gamma Subunit Transducin beta-Transducin beta-Transducin beta Transducin Transducin, beta Subunit beta Subunit Transducin alpha-Transducin alpha-Transducin alpha Transducin Transducin, alpha Subunit alpha Subunit Transducin

Below are MeSH descriptors whose meaning is more general than "Transducin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
Transducin [D08.811.277.040.330.300.200.800]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Heterotrimeric GTP-Binding Proteins [D12.644.360.360]
Transducin [D12.644.360.360.940]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
Transducin [D12.776.157.325.332.940]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
Transducin [D12.776.476.375.940]
Membrane Proteins [D12.776.543]
Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
Transducin [D12.776.543.325.800]

Below are MeSH descriptors whose meaning is related to "Transducin".

Below are MeSH descriptors whose meaning is more specific than "Transducin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transducin" by people in this website by year, and whether "Transducin" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 1997 and 2005 and 2009 and 2010 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
2005	0	1	1
2009	0	1	1
2010	0	1	1
2021	1	0	1

Below are the most recent publications written about "Transducin" by people in Profiles.

Soldi R, Halder TG, Sampson S, Vankayalapati H, Weston A, Thode T, Bhalla KN, Ng S, Rodriguez Del Villar R, Drenner K, Kaadige MR, Horrigan SK, Batra SK, Salgia R, Sharma S. The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ?-Like 1-?-Catenin Protein Complex. J Pharmacol Exp Ther. 2021 Aug; 378(2):77-86.

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Komolov KE, Koch KW. Application of surface plasmon resonance spectroscopy to study G-protein coupled receptor signalling. Methods Mol Biol. 2010; 627:249-60.

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Wang D, Xia X, Liu Y, Oetting A, Walker RL, Zhu Y, Meltzer P, Cole PA, Shi YB, Yen PM. Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. Mol Endocrinol. 2009 May; 23(5):600-9.

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Daniele LL, Lillo C, Lyubarsky AL, Nikonov SS, Philp N, Mears AJ, Swaroop A, Williams DS, Pugh EN. Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):2156-67.

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Krupnick JG, Gurevich VV, Benovic JL. Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin. J Biol Chem. 1997 Jul 18; 272(29):18125-31.

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Richardson RM, Kim C, Benovic JL, Hosey MM. Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase. J Biol Chem. 1993 Jun 25; 268(18):13650-6.

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Krupinski J, Rajaram R, Lakonishok M, Benovic JL, Cerione RA. Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles. J Biol Chem. 1988 Sep 05; 263(25):12333-41.

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Cerione RA, Gierschik P, Staniszewski C, Benovic JL, Codina J, Somers R, Birnbaumer L, Spiegel AM, Lefkowitz RJ, Caron MG. Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. Biochemistry. 1987 Mar 10; 26(5):1485-91.

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Cerione RA, Regan JW, Nakata H, Codina J, Benovic JL, Gierschik P, Somers RL, Spiegel AM, Birnbaumer L, Lefkowitz RJ, et al. Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J Biol Chem. 1986 Mar 15; 261(8):3901-9.

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Grunwald GB, Gierschik P, Nirenberg M, Spiegel A. Detection of alpha-transducin in retinal rods but not cones. Science. 1986 Feb 21; 231(4740):856-9.

View in: PubMed

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