GTP-Binding Protein alpha Subunits

"GTP-Binding Protein alpha Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.

Descriptor ID	D044385
MeSH Number(s)	D08.811.277.040.330.300.200.100 D12.644.360.360.100 D12.776.157.325.332.100 D12.776.476.375.100 D12.776.543.325.100
Concept/Terms	GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits GTP Binding Protein alpha Subunits G-Protein alpha Subunit G Protein alpha Subunit alpha Subunit, G-Protein GTP-Binding Protein alpha Subunit GTP Binding Protein alpha Subunit

Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Heterotrimeric GTP-Binding Proteins [D12.644.360.360]
GTP-Binding Protein alpha Subunits [D12.644.360.360.100]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
GTP-Binding Protein alpha Subunits [D12.776.476.375.100]
Membrane Proteins [D12.776.543]
Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
GTP-Binding Protein alpha Subunits [D12.776.543.325.100]

Below are MeSH descriptors whose meaning is related to "GTP-Binding Protein alpha Subunits".

Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits".

GTP-Binding Protein alpha Subunits
GTP-Binding Protein alpha Subunits, G12-G13
GTP-Binding Protein alpha Subunits, Gi-Go
GTP-Binding Protein alpha Subunits, Gq-G11
GTP-Binding Protein alpha Subunits, Gs

publications

Timeline | Most Recent

This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2004	1	1	2
2005	1	0	1
2007	0	1	1
2014	0	1	1
2017	0	1	1
2018	1	0	1
2022	0	1	1
2024	1	0	1

Below are the most recent publications written about "GTP-Binding Protein alpha Subunits" by people in Profiles.

Dimitriou F, Orloff MM, Koch Hein EC, Cheng PF, Hughes IF, Simeone E, Montazeri K, Grover P, Mehmi I, Gerard CL, Gaudy-Marqueste C, Grob JJ, Michielin O, Hamid O, Long GV, Sullivan R, Kapiteijn E, Johnson DB, Ascierto PA, Joshua AM, Carvajal RD, Butler MO, Hassel JC, Dummer R. Treatment sequence with tebentafusp and immune checkpoint inhibitors in patients with metastatic uveal melanoma and metastatic GNA11/GNAQ mutant melanocytic tumors. Eur J Cancer. 2025 Jan; 214:115161.

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Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC, Bastian BC, Bloomer MM, Pekmezci M. Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations. Ophthalmology. 2022 12; 129(12):1429-1439.

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Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso J, Benovic JL. Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. 2019 04; 17(4):963-973.

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Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE. Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. Mol Cancer Res. 2017 05; 15(5):501-506.

View in: PubMed
Barski JJ, Denker BM, Guan J, Lauth M, Spreafico F, Fertala A, Meyer M. Developmental upregulation of an alternative form of pcp2 with reduced GDI activity. Cerebellum. 2014 Apr; 13(2):207-14.

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Pleger ST, Boucher M, Most P, Koch WJ. Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy. J Card Fail. 2007 Jun; 13(5):401-14.

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Corradi JP, Ravyn V, Robbins AK, Hagan KW, Peters MF, Bostwick R, Buono RJ, Berrettini WH, Furlong ST. Alternative transcripts and evidence of imprinting of GNAL on 18p11.2. Mol Psychiatry. 2005 Nov; 10(11):1017-25.

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Iczkowski KA, Omara-Opyene AL, Kl?sel R. Metafectene is superior to lipofectamine in the transfection of G(s) alpha prostate cancer cells. Mol Biotechnol. 2004 Oct; 28(2):97-103.

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Day PW, Wedegaertner PB, Benovic JL. Analysis of G-protein-coupled receptor kinase RGS homology domains. Methods Enzymol. 2004; 390:295-310.

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Berrettini WH, Vuoristo J, Ferraro TN, Buono RJ, Wildenauer D, Ala-Kokko L. Human G(olf) gene polymorphisms and vulnerability to bipolar disorder. Psychiatr Genet. 1998; 8(4):235-8.

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