"Platelet Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
| Descriptor ID |
D015539
|
| MeSH Number(s) |
G09.188.390.600
|
| Concept/Terms |
Platelet Activation- Platelet Activation
- Activation, Platelet
- Activations, Platelet
- Platelet Activations
|
Below are MeSH descriptors whose meaning is more general than "Platelet Activation".
Below are MeSH descriptors whose meaning is more specific than "Platelet Activation".
This graph shows the total number of publications written about "Platelet Activation" by people in this website by year, and whether "Platelet Activation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 3 | 3 |
| 2003 | 0 | 3 | 3 |
| 2005 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 4 | 1 | 5 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 3 | 4 |
| 2014 | 5 | 0 | 5 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 1 | 3 |
| 2017 | 1 | 1 | 2 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 4 | 4 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Platelet Activation" by people in Profiles.
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Nigam A, Manjuprasanna VN, Naik MU, Naik UP. Platelet spreading and clot retraction are regulated by 2 distinct aIIb?3 outside-in signaling pathways. J Pharmacol Exp Ther. 2025 01; 392(1):100012.
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Marar TT, Martinez ND, Maroney SA, Siebert AE, Wu J, Stalker TJ, Tomaiuolo M, Delacroix S, Simari RD, Mast AE, Brass LF. The contribution of TFPIa to the hemostatic response to injury in mice. J Thromb Haemost. 2021 09; 19(9):2182-2192.
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Patel P, Michael JV, Naik UP, McKenzie SE. Platelet Fc?RIIA in immunity and thrombosis: Adaptive immunothrombosis. J Thromb Haemost. 2021 05; 19(5):1149-1160.
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Shaik NF, Regan RF, Naik UP. Platelets as drivers of ischemia/reperfusion injury after stroke. Blood Adv. 2021 03 09; 5(5):1576-1584.
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Abraham S, Ma L, Kong X, Askari S, Edelstein LC, McKenzie SE. PCTP contributes to human platelet activation by enhancing dense granule secretion. Thromb Res. 2021 06; 202:67-73.
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Patel P, Shaik NF, Zhou Y, Golla K, McKenzie SE, Naik UP. Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock. J Thromb Haemost. 2020 11; 18(11):3013-3028.
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Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. Blood Adv. 2020 01 14; 4(1):76-86.
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Patel P, Naik MU, Golla K, Shaik NF, Naik UP. Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets. Biochem J. 2019 10 15; 476(19):2835-2850.
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Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, Bray PF. miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. J Thromb Haemost. 2019 03; 17(3):511-524.
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Tomaiuolo M, Matzko CN, Poventud-Fuentes I, Weisel JW, Brass LF, Stalker TJ. Interrelationships between structure and function during the hemostatic response to injury. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2243-2252.