"Cytochalasin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.
| Descriptor ID |
D015638
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| MeSH Number(s) |
D03.633.100.473.231.450 D23.946.587.370.450
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cytochalasin D".
Below are MeSH descriptors whose meaning is more specific than "Cytochalasin D".
This graph shows the total number of publications written about "Cytochalasin D" by people in this website by year, and whether "Cytochalasin D" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytochalasin D" by people in Profiles.
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Fregin B, Czerwinski F, Biedenweg D, Girardo S, Gross S, Aurich K, Otto O. High-throughput single-cell rheology in complex samples by dynamic real-time deformability cytometry. Nat Commun. 2019 01 24; 10(1):415.
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Otto O, Rosendahl P, Mietke A, Golfier S, Herold C, Klaue D, Girardo S, Pagliara S, Ekpenyong A, Jacobi A, Wobus M, T?pfner N, Keyser UF, Mansfeld J, Fischer-Friedrich E, Guck J. Real-time deformability cytometry: on-the-fly cell mechanical phenotyping. Nat Methods. 2015 Mar; 12(3):199-202, 4 p following 202.
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Lazarus MD, Schneider TG, Taraschi TF. A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum. J Cell Sci. 2008 Jun 01; 121(11):1937-49.
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Zhang J, Ryder KD, Bethel JA, Ramirez R, Duncan RL. PTH-induced actin depolymerization increases mechanosensitive channel activity to enhance mechanically stimulated Ca2+ signaling in osteoblasts. J Bone Miner Res. 2006 Nov; 21(11):1729-37.
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Weber GF, Menko AS. Actin filament organization regulates the induction of lens cell differentiation and survival. Dev Biol. 2006 Jul 15; 295(2):714-29.
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Hayduk EJ, Lee KH. Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells. Biotechnol Bioeng. 2005 May 05; 90(3):354-64.
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Aplin AE, Stewart SA, Assoian RK, Juliano RL. Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. J Cell Biol. 2001 Apr 16; 153(2):273-82.
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Fuki IV, Iozzo RV, Williams KJ. Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism. J Biol Chem. 2000 Aug 18; 275(33):25742-50.
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Aplin AE, Juliano RL. Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway. J Cell Sci. 1999 Mar; 112 ( Pt 5):695-706.
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Pomidor MM, Ruhl KK, Zheng P, Song Y, J?nne OA, Tuan RS, Hickok NJ. Relationship between ornithine decarboxylase and cytoskeletal organization in cultured human keratinocytes: cellular responses to phorbol esters, cytochalasins, and alpha-difluoromethylornithine. Exp Cell Res. 1995 Dec; 221(2):426-37.