Genes, Tumor Suppressor

"Genes, Tumor Suppressor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

Descriptor ID	D016147
MeSH Number(s)	G05.360.340.024.340.375.249 G05.360.340.024.340.415.400
Concept/Terms	Genes, Tumor Suppressor Genes, Tumor Suppressor Gene, Tumor Suppressor Tumor Suppressor Gene Antioncogenes Antioncogene Emerogenes Emerogene Genes, Onco-Suppressor Gene, Onco-Suppressor Genes, Onco Suppressor Onco-Suppressor Gene Onco-Suppressor Genes Cancer Suppressor Genes Cancer Suppressor Gene Gene, Cancer Suppressor Suppressor Gene, Cancer Suppressor Genes, Cancer Oncogenes, Recessive Oncogene, Recessive Recessive Oncogene Recessive Oncogenes Anti-Oncogenes Anti Oncogenes Anti-Oncogene Tumor Suppressing Genes Gene, Tumor Suppressing Genes, Tumor Suppressing Tumor Suppressing Gene Genes, Cancer Suppressor Tumor Suppressor Genes Metastasis Suppressor Genes Metastasis Suppressor Genes Gene, Metastasis Suppressor Metastasis Suppressor Gene Suppressor Gene, Metastasis Suppressor Genes, Metastasis Genes, Metastasis Suppressor Growth Suppressor Genes Growth Suppressor Genes Gene, Growth Suppressor Growth Suppressor Gene Suppressor Gene, Growth Suppressor Genes, Growth Genes, Growth Suppressor

Below are MeSH descriptors whose meaning is more general than "Genes, Tumor Suppressor".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Neoplasm [G05.360.340.024.340.375]
Genes, Tumor Suppressor [G05.360.340.024.340.375.249]
Genes, Recessive [G05.360.340.024.340.415]
Genes, Tumor Suppressor [G05.360.340.024.340.415.400]

Below are MeSH descriptors whose meaning is related to "Genes, Tumor Suppressor".

Below are MeSH descriptors whose meaning is more specific than "Genes, Tumor Suppressor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, Tumor Suppressor" by people in this website by year, and whether "Genes, Tumor Suppressor" was a major or minor topic of these publications.

Bar chart showing 93 publications over 23 distinct years, with a maximum of 10 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	4	1	5
1997	5	1	6
1998	5	4	9
1999	3	3	6
2000	6	4	10
2001	5	3	8
2002	0	6	6
2003	3	4	7
2004	2	3	5
2005	0	2	2
2006	0	4	4
2007	1	0	1
2008	5	1	6
2009	0	3	3
2010	0	2	2
2011	1	0	1
2013	1	0	1
2014	1	1	2
2016	1	1	2
2019	1	0	1
2020	1	1	2
2021	1	2	3
2023	0	1	1

Below are the most recent publications written about "Genes, Tumor Suppressor" by people in Profiles.

Jirka GW, Lefler DS, Russo J, Bashir B. Colon adenocarcinoma and Birt-Hogg-Dub? syndrome in a young patient: case report and exploration of pathologic implications. Cancer Biol Ther. 2023 12 31; 24(1):2184153.

View in: PubMed
Park J, Daniels J, Wartewig T, Ringbloom KG, Martinez-Escala ME, Choi S, Thomas JJ, Doukas PG, Yang J, Snowden C, Law C, Lee Y, Lee K, Zhang Y, Conran C, Tegtmeyer K, Mo SH, Pease DR, Jothishankar B, Kwok PY, Abdulla FR, Pro B, Louissaint A, Boggon TJ, Sosman J, Guitart J, Rao D, Ruland J, Choi J. Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity. Blood. 2021 10 07; 138(14):1225-1236.

View in: PubMed
Imeri F, Stepanovska Tanturovska B, Schwalm S, Saha S, Zeng-Brouwers J, Pavenst?dt H, Pfeilschifter J, Schaefer L, Huwiler A. Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. Matrix Biol. 2021 04; 98:32-48.

View in: PubMed
Han A, Purwin TJ, Aplin AE. Roles of the BAP1 Tumor Suppressor in Cell Metabolism. Cancer Res. 2021 06 01; 81(11):2807-2814.

View in: PubMed
Pattison AM, Barton JR, Entezari AA, Zalewski A, Rappaport JA, Snook AE, Waldman SA. Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. Cancer Biol Ther. 2020 09 01; 21(9):799-805.

View in: PubMed
Blomain ES, Rappaport JA, Pattison AM, Bashir B, Caparosa E, Stem J, Snook AE, Waldman SA. APC-?-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. Cancer Biol Ther. 2020 05 03; 21(5):441-451.

View in: PubMed
Banerjee S, Corless CL, Miettinen MM, Noh S, Ustoy R, Davis JL, Tang CM, Yebra M, Burgoyne AM, Sicklick JK. Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma. J Transl Med. 2019 07 30; 17(1):246.

View in: PubMed
Kopczynski J, Kowalik A, Chlopek M, Wang ZF, G?zdz S, Lasota J, Miettinen M. Oncogenic Activation of the Wnt/?-Catenin Signaling Pathway in Signet Ring Stromal Cell Tumor of the Ovary. Appl Immunohistochem Mol Morphol. 2016 May-Jun; 24(5):e28-33.

View in: PubMed
Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations. Cancer Res. 2016 05 01; 76(9):2836-44.

View in: PubMed
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevic N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni AM, Gould D, Lorincz AT, Oliver RT, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD, Lu YJ. Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol. 2014 Apr; 232(5):566-77.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement