"Genes, Retinoblastoma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
Descriptor ID |
D016161
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MeSH Number(s) |
G05.360.340.024.340.375.249.400 G05.360.340.024.340.415.400.400
|
Concept/Terms |
Genes, Retinoblastoma- Genes, Retinoblastoma
- Rb Genes
- Retinoblastoma Genes
- Gene, Retinoblastoma
- Retinoblastoma Gene
- Genes, Rb
- Gene, Rb
- Rb Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, Retinoblastoma".
Below are MeSH descriptors whose meaning is more specific than "Genes, Retinoblastoma".
This graph shows the total number of publications written about "Genes, Retinoblastoma" by people in this website by year, and whether "Genes, Retinoblastoma" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2001 | 0 | 1 | 1 |
2002 | 1 | 0 | 1 |
2003 | 1 | 0 | 1 |
2010 | 1 | 1 | 2 |
2011 | 1 | 0 | 1 |
2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, Retinoblastoma" by people in Profiles.
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Indovina P, Marcelli E, Casini N, Rizzo V, Giordano A. Emerging roles of RB family: new defense mechanisms against tumor progression. J Cell Physiol. 2013 Mar; 228(3):525-35.
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Witkiewicz AK, Rivadeneira DB, Ertel A, Kline J, Hyslop T, Schwartz GF, Fortina P, Knudsen ES. Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment. Am J Pathol. 2011 Sep; 179(3):1171-8.
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Sharma A, Yeow WS, Ertel A, Coleman I, Clegg N, Thangavel C, Morrissey C, Zhang X, Comstock CE, Witkiewicz AK, Gomella L, Knudsen ES, Nelson PS, Knudsen KE. The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression. J Clin Invest. 2010 Dec; 120(12):4478-92.
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McClendon AK, Dean JL, Ertel A, Knudsen ES. Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model. PLoS One. 2010; 5(1):e8558.
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Sanseverino F, Torricelli M, Petraglia F, Giordano A. Role of the retinoblastoma family in gynecological cancer. Cancer Biol Ther. 2003 Nov-Dec; 2(6):636-41.
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Claudio PP, Tonini T, Giordano A. The retinoblastoma family: twins or distant cousins? Genome Biol. 2002 Aug 28; 3(9):reviews3012.
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Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM. Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding. Oncogene. 2001 Aug 9; 20(35):4827-41.