"Methacholine Chloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
| Descriptor ID |
D016210
|
| MeSH Number(s) |
D02.092.877.883.555.500 D02.675.276.534.500
|
| Concept/Terms |
Methacholine Chloride- Methacholine Chloride
- Chloride, Methacholine
- Acetyl-beta-methacholine Chloride
- Acetyl beta methacholine Chloride
- Mecholine
- 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
- Acetyl-2-methylcholine Chloride
- Acetyl 2 methylcholine Chloride
|
Below are MeSH descriptors whose meaning is more general than "Methacholine Chloride".
Below are MeSH descriptors whose meaning is more specific than "Methacholine Chloride".
This graph shows the total number of publications written about "Methacholine Chloride" by people in this website by year, and whether "Methacholine Chloride" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 2001 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 2 | 3 |
| 2015 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Methacholine Chloride" by people in Profiles.
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Tompkins E, Mimic B, Penn RB, Pera T. The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype. J Biol Chem. 2023 10; 299(10):105209.
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Wang Y, Miwa T, Ducka-Kokalari B, Redai IG, Sato S, Gullipalli D, Zangrilli JG, Haczku A, Song WC. Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation. J Immunol. 2015 Aug 01; 195(3):1171-81.
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Rodriguez E, Sakowski L, Hobson GM, Armani MH, Kreiger PA, Zhu Y, Waldman SA, Shaffer TH. Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation. Pulm Pharmacol Ther. 2015 Feb; 30:22-31.
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Rodriguez E, Barthold JS, Kreiger PA, Armani MH, Wang J, Michelini KA, Wolfson MR, Boyce R, Barone CA, Zhu Y, Waldman SA, Shaffer TH. The orl rat is more responsive to methacholine challenge than wild type. Pulm Pharmacol Ther. 2014 Dec; 29(2):199-208.
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Sharma P, Basu S, Mitchell RW, Stelmack GL, Anderson JE, Halayko AJ. Role of dystrophin in airway smooth muscle phenotype, contraction and lung function. PLoS One. 2014; 9(7):e102737.
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Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60.
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Holgate ST, Noonan M, Chanez P, Busse W, Dupont L, Pavord I, Hakulinen A, Paolozzi L, Wajdula J, Zang C, Nelson H, Raible D. Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial. Eur Respir J. 2011 Jun; 37(6):1352-9.
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Pera T, Gosens R, Lesterhuis AH, Sami R, van der Toorn M, Zaagsma J, Meurs H. Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. Respir Res. 2010 Apr 29; 11:48.
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Johnston RA, Theman TA, Lu FL, Terry RD, Williams ES, Shore SA. Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. J Appl Physiol (1985). 2008 Jun; 104(6):1727-35.
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Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG. Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide. J Allergy Clin Immunol. 2006 Dec; 118(6):1218-25.