"PrPC Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
| Descriptor ID |
D018621
|
| MeSH Number(s) |
D12.776.785.340.500
|
| Concept/Terms |
PrPC Proteins- PrPC Proteins
- PrP-sen
- PrP sen
- Cp 33-35
- Scrapie Amyloid Precursor Protein
- Cp33-35, Scrapie
|
Below are MeSH descriptors whose meaning is more general than "PrPC Proteins".
Below are MeSH descriptors whose meaning is more specific than "PrPC Proteins".
This graph shows the total number of publications written about "PrPC Proteins" by people in this website by year, and whether "PrPC Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "PrPC Proteins" by people in Profiles.
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Ghosh S, Jana R, Jana S, Basu R, Chatterjee M, Ranawat N, Das Sarma J. Differential expression of cellular prion protein (PrPC) in mouse hepatitis virus induced neuroinflammation. J Neurovirol. 2024 06; 30(3):215-228.
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Ashok A, Kang MH, Wise AS, Pattabiraman P, Johnson WM, Lonigro M, Ravikumar R, Rhee DJ, Singh N. Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma. Sci Rep. 2019 09 11; 9(1):13090.
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Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Elife. 2017 05 20; 6.
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Colby DW, Prusiner SB. Prions. Cold Spring Harb Perspect Biol. 2011 Jan 01; 3(1):a006833.