Spheroids, Cellular

"Spheroids, Cellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)

Descriptor ID	D018874
MeSH Number(s)	A11.251.800
Concept/Terms	Spheroids, Cellular Spheroids, Cellular Cellular Spheroid Cellular Spheroids Spheroid, Cellular Multicellular Spheroids Multicellular Spheroid Spheroid, Multicellular Spheroids, Multicellular

Below are MeSH descriptors whose meaning is more general than "Spheroids, Cellular".

Anatomy [A]
Cells [A11]
Cells, Cultured [A11.251]
Spheroids, Cellular [A11.251.800]

Below are MeSH descriptors whose meaning is related to "Spheroids, Cellular".

Below are MeSH descriptors whose meaning is more specific than "Spheroids, Cellular".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spheroids, Cellular" by people in this website by year, and whether "Spheroids, Cellular" was a major or minor topic of these publications.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 4 publications in 2010 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2004	0	1	1
2006	0	2	2
2008	0	1	1
2009	0	2	2
2010	2	2	4
2011	0	1	1
2012	1	3	4
2013	0	3	3
2014	0	1	1
2015	2	1	3
2016	0	1	1
2017	0	1	1
2018	1	2	3
2019	2	1	3
2021	0	1	1
2024	1	0	1

Below are the most recent publications written about "Spheroids, Cellular" by people in Profiles.

Dogan E, Galifi CA, Cecen B, Shukla R, Wood TL, Miri AK. Extracellular matrix regulation of cell spheroid invasion in a 3D bioprinted solid tumor-on-a-chip. Acta Biomater. 2024 09 15; 186:156-166.

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Darrigues E, Zhao EH, De Loose A, Lee MP, Borrelli MJ, Eoff RL, Galileo DS, Penthala NR, Crooks PA, Rodriguez A. Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion. Int J Mol Sci. 2021 Oct 03; 22(19).

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Nacarelli T, Fukumoto T, Zundell JA, Fatkhutdinov N, Jean S, Cadungog MG, Borowsky ME, Zhang R. NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer. Cancer Res. 2020 02 15; 80(4):890-900.

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Taubenberger AV, Girardo S, Tr?ber N, Fischer-Friedrich E, Kr?ter M, Wagner K, Kurth T, Richter I, Haller B, Binner M, Hahn D, Freudenberg U, Werner C, Guck J. 3D Microenvironment Stiffness Regulates Tumor Spheroid Growth and Mechanics via p21 and ROCK. Adv Biosyst. 2019 09; 3(9):e1900128.

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Vining KH, Lombaert IMA, Patel VN, Kibbey SE, Pradhan-Bhatt S, Witt RL, Hoffman MP. Neurturin-containing laminin matrices support innervated branching epithelium from adult epithelial salispheres. Biomaterials. 2019 09; 216:119245.

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Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO, Harris AL. 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers. Mol Cancer Ther. 2019 02; 18(2):376-388.

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Barbarino M, Cesari D, Intruglio R, Indovina P, Namagerdi A, Bertolino FM, Bottaro M, Rahmani D, Bellan C, Giordano A. Possible repurposing of pyrvinium pamoate for the treatment of mesothelioma: A pre-clinical assessment. J Cell Physiol. 2018 09; 233(9):7391-7401.

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Ezquer F, Morales P, Quintanilla ME, Santapau D, Lespay-Rebolledo C, Ezquer M, Herrera-Marschitz M, Israel Y. Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking. Sci Rep. 2018 03 22; 8(1):4325.

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Ozdemir T, Srinivasan PP, Zakheim DR, Harrington DA, Witt RL, Farach-Carson MC, Jia X, Pradhan-Bhatt S. Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function. Biomaterials. 2017 Oct; 142:124-135.

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Takai A, Fako V, Dang H, Forgues M, Yu Z, Budhu A, Wang XW. Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma. Sci Rep. 2016 Feb 16; 6:21174.

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