F-Box Proteins

"F-Box Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.

Descriptor ID	D044783
MeSH Number(s)	D12.776.157.169
Concept/Terms	F-Box Proteins F-Box Proteins F Box Proteins F-Box Domain Protein Domain Protein, F-Box F Box Domain Protein Protein, F-Box Domain F-Box Protein Family F Box Protein Family Protein Family, F-Box

Below are MeSH descriptors whose meaning is more general than "F-Box Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
F-Box Proteins [D12.776.157.169]

Below are MeSH descriptors whose meaning is related to "F-Box Proteins".

Below are MeSH descriptors whose meaning is more specific than "F-Box Proteins".

F-Box Proteins
beta-Transducin Repeat-Containing Proteins
F-Box-WD Repeat-Containing Protein 7

publications

Timeline | Most Recent

This graph shows the total number of publications written about "F-Box Proteins" by people in this website by year, and whether "F-Box Proteins" was a major or minor topic of these publications.

Bar chart showing 6 publications over 6 distinct years, with a maximum of 1 publications in 2003 and 2006 and 2010 and 2011 and 2015 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2006	1	0	1
2010	0	1	1
2011	1	0	1
2015	1	0	1
2024	0	1	1

Below are the most recent publications written about "F-Box Proteins" by people in Profiles.

Nie DY, Tabor JR, Li J, Kutera M, St-Germain J, Hanley RP, Wolf E, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Maitland MER, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Penn LZ, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht JD, James LI, Arrowsmith CH. Recruitment of FBXO22 for targeted degradation of NSD2. Nat Chem Biol. 2024 Dec; 20(12):1597-1607.

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Lian Z, Lee EK, Bass AJ, Wong KK, Klein-Szanto AJ, Rustgi AK, Diehl JA. FBXO4 loss facilitates carcinogen induced papilloma development in mice. Cancer Biol Ther. 2015; 16(5):750-5.

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Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA. The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol. 2011 Nov; 31(22):4513-23.

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Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, Diehl JA. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010 Oct 19; 18(4):329-40.

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Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell. 2006 Nov 03; 24(3):355-66.

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Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, Valentine V, Hempen PM, Hilgers W, Yeo CJ, Hruban RH, Kern SE. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol. 2003 Oct; 163(4):1255-60.

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