Penicillin-Binding Proteins
"Penicillin-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
| Descriptor ID |
D046915
|
| MeSH Number(s) |
D08.811.710 D12.776.097.545
|
| Concept/Terms |
Penicillin-Binding Proteins- Penicillin-Binding Proteins
- Penicillin Binding Proteins
- Proteins, Penicillin-Binding
- Penicillin-Binding Protein
- Penicillin Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Penicillin-Binding Proteins".
Below are MeSH descriptors whose meaning is more specific than "Penicillin-Binding Proteins".
This graph shows the total number of publications written about "Penicillin-Binding Proteins" by people in this website by year, and whether "Penicillin-Binding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Penicillin-Binding Proteins" by people in Profiles.
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Nair DR, Monteiro JM, Memmi G, Thanassi J, Pucci M, Schwartzman J, Pinho MG, Cheung AL. Characterization of a novel small molecule that potentiates ?-lactam activity against gram-positive and gram-negative pathogens. Antimicrob Agents Chemother. 2015 Apr; 59(4):1876-85.
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Pucci MJ, Dougherty TJ. A method to assay penicillin-binding proteins. Methods Mol Med. 2008; 142:131-41.
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Johnson WH, Wang SC, Stanley TM, Czerwinski RM, Almrud JJ, Poelarends GJ, Murzin AG, Whitman CP. 4-Oxalocrotonate tautomerase, its homologue YwhB, and active vinylpyruvate hydratase: synthesis and evaluation of 2-fluoro substrate analogues. Biochemistry. 2004 Aug 17; 43(32):10490-501.
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Wang SC, Johnson WH, Czerwinski RM, Whitman CP. Reactions of 4-oxalocrotonate tautomerase and YwhB with 3-halopropiolates: analysis and implications. Biochemistry. 2004 Jan 27; 43(3):748-58.
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Wang SC, Johnson WH, Whitman CP. The 4-oxalocrotonate tautomerase- and YwhB-catalyzed hydration of 3E-haloacrylates: implications for the evolution of new enzymatic activities. J Am Chem Soc. 2003 Nov 26; 125(47):14282-3.
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Fung-Tomc JC, Clark J, Minassian B, Pucci M, Tsai YH, Gradelski E, Lamb L, Medina I, Huczko E, Kolek B, Chaniewski S, Ferraro C, Washo T, Bonner DP. In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against methicillin-resistant and -susceptible staphylococci. Antimicrob Agents Chemother. 2002 Apr; 46(4):971-6.
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Pucci MJ, Dougherty TJ. Direct quantitation of the numbers of individual penicillin-binding proteins per cell in Staphylococcus aureus. J Bacteriol. 2002 Jan; 184(2):588-91.