"DNA Topoisomerase IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
| Descriptor ID |
D027101
|
| MeSH Number(s) |
D08.811.399.403.741.224 D12.776.097.256
|
| Concept/Terms |
parC Protein- parC Protein
- parC Gene Product, Topo IV
- Topoisomerase IV Subunit A
- parC Gene Product
parE Protein- parE Protein
- parE Gene Product, Topo IV
- Topoisomerase IV Subunit B
- parE Gene Product
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerase IV".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerase IV".
This graph shows the total number of publications written about "DNA Topoisomerase IV" by people in this website by year, and whether "DNA Topoisomerase IV" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 3 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "DNA Topoisomerase IV" by people in Profiles.
-
Kim HY, Wiles JA, Wang Q, Pais GC, Lucien E, Hashimoto A, Nelson DM, Thanassi JA, Podos SD, Deshpande M, Pucci MJ, Bradbury BJ. Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA). J Med Chem. 2011 May 12; 54(9):3268-82.
-
Wiles JA, Phadke AS, Bradbury BJ, Pucci MJ, Thanassi JA, Deshpande M. Selenophene-containing inhibitors of type IIA bacterial topoisomerases. J Med Chem. 2011 May 12; 54(9):3418-25.
-
Pucci MJ, Podos SD, Thanassi JA, Leggio MJ, Bradbury BJ, Deshpande M. In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens. Antimicrob Agents Chemother. 2011 Jun; 55(6):2860-71.
-
Cheng J, Thanassi JA, Thoma CL, Bradbury BJ, Deshpande M, Pucci MJ. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. Antimicrob Agents Chemother. 2007 Jul; 51(7):2445-53.
-
Wiles JA, Hashimoto A, Thanassi JA, Cheng J, Incarvito CD, Deshpande M, Pucci MJ, Bradbury BJ. Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. J Med Chem. 2006 Jan 12; 49(1):39-42.