Glutamate Plasma Membrane Transport Proteins

"Glutamate Plasma Membrane Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of plasma membrane neurotransmitter transporter proteins that couple the uptake of GLUTAMATE with the import of SODIUM ions and PROTONS and the export of POTASSIUM ions. In the CENTRAL NERVOUS SYSTEM they regulate neurotransmission through synaptic reuptake of the excitatory neurotransmitter glutamate. Outside the central nervous system they function as signal mediators and regulators of glutamate metabolism.

Descriptor ID	D050491
MeSH Number(s)	D12.776.157.530.200.249.500.500 D12.776.157.530.450.625.147 D12.776.157.530.562.374.781 D12.776.157.530.937.250.500 D12.776.543.585.200.249.500.500 D12.776.543.585.450.625.147 D12.776.543.585.562.374.781 D12.776.543.585.937.250.500
Concept/Terms	Glutamate Plasma Membrane Transport Proteins Glutamate Plasma Membrane Transport Proteins Neurotransmitter Transporters, Glutamate-Specific Glutamate-Specific Neurotransmitter Transporters Neurotransmitter Transporters, Glutamate Specific Transporters, Glutamate-Specific Neurotransmitter Neurotransmitter Transport Proteins, Glutamate-Specific Neurotransmitter Transport Proteins, Glutamate Specific Glutamate Plasma Membrane Transporter Proteins Sodium-Glutamate Cotransporter Sodium-Glutamate Cotransporter Cotransporter, Sodium-Glutamate Sodium Glutamate Cotransporter Sodium-Glutamate Transporter Sodium Glutamate Transporter Excitatory Amino Acid Transporter Proteins Excitatory Amino Acid Transporter Proteins Excitatory Amino Acid Transport Proteins EAAT Proteins

Below are MeSH descriptors whose meaning is more general than "Glutamate Plasma Membrane Transport Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Amino Acid Transport Systems [D12.776.157.530.200]
Amino Acid Transport Systems, Acidic [D12.776.157.530.200.249]
Amino Acid Transport System X-AG [D12.776.157.530.200.249.500]
Glutamate Plasma Membrane Transport Proteins [D12.776.157.530.200.249.500.500]
Ion Pumps [D12.776.157.530.450]
Symporters [D12.776.157.530.450.625]
Glutamate Plasma Membrane Transport Proteins [D12.776.157.530.450.625.147]
Neurotransmitter Transport Proteins [D12.776.157.530.562]
Plasma Membrane Neurotransmitter Transport Proteins [D12.776.157.530.562.374]
Glutamate Plasma Membrane Transport Proteins [D12.776.157.530.562.374.781]
Solute Carrier Proteins [D12.776.157.530.937]
Amino Acid Transport System X-AG [D12.776.157.530.937.250]
Glutamate Plasma Membrane Transport Proteins [D12.776.157.530.937.250.500]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Amino Acid Transport Systems [D12.776.543.585.200]
Amino Acid Transport Systems, Acidic [D12.776.543.585.200.249]
Amino Acid Transport System X-AG [D12.776.543.585.200.249.500]
Glutamate Plasma Membrane Transport Proteins [D12.776.543.585.200.249.500.500]
Ion Pumps [D12.776.543.585.450]
Symporters [D12.776.543.585.450.625]
Glutamate Plasma Membrane Transport Proteins [D12.776.543.585.450.625.147]
Neurotransmitter Transport Proteins [D12.776.543.585.562]
Plasma Membrane Neurotransmitter Transport Proteins [D12.776.543.585.562.374]
Glutamate Plasma Membrane Transport Proteins [D12.776.543.585.562.374.781]
Solute Carrier Proteins [D12.776.543.585.937]
Amino Acid Transport System X-AG [D12.776.543.585.937.250]
Glutamate Plasma Membrane Transport Proteins [D12.776.543.585.937.250.500]

Below are MeSH descriptors whose meaning is related to "Glutamate Plasma Membrane Transport Proteins".

Below are MeSH descriptors whose meaning is more specific than "Glutamate Plasma Membrane Transport Proteins".

Glutamate Plasma Membrane Transport Proteins
Excitatory Amino Acid Transporter 1
Excitatory Amino Acid Transporter 2
Excitatory Amino Acid Transporter 3
Excitatory Amino Acid Transporter 4
Excitatory Amino Acid Transporter 5

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glutamate Plasma Membrane Transport Proteins" by people in this website by year, and whether "Glutamate Plasma Membrane Transport Proteins" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2004	0	2	2
2006	1	0	1
2010	1	0	1
2013	0	1	1
2014	1	0	1
2015	0	1	1
2017	1	0	1

Below are the most recent publications written about "Glutamate Plasma Membrane Transport Proteins" by people in Profiles.

Rosenblum LT, Trotti D. EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis. Adv Neurobiol. 2017; 16:117-136.

View in: PubMed
Li K, Javed E, Scura D, Hala TJ, Seetharam S, Falnikar A, Richard JP, Chorath A, Maragakis NJ, Wright MC, Lepore AC. Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury. Exp Neurol. 2015 Sep; 271:479-92.

View in: PubMed
Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia. 2014 Aug; 62(8):1241-53.

View in: PubMed
Foran E, Rosenblum L, Bogush AI, Trotti D. Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis. Neuromolecular Med. 2013 Dec; 15(4):760-70.

View in: PubMed
Woltjer RL, Duerson K, Fullmer JM, Mookherjee P, Ryan AM, Montine TJ, Kaye JA, Quinn JF, Silbert L, Erten-Lyons D, Leverenz JB, Bird TD, Pow DV, Tanaka K, Watson GS, Cook DG. Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease. J Neuropathol Exp Neurol. 2010 Jul; 69(7):667-76.

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Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem. 2006 May 19; 281(20):14076-84.

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Butchbach ME, Tian G, Guo H, Lin CL. Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function. J Biol Chem. 2004 Aug 13; 279(33):34388-96.

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Yang Y, Kinney GA, Spain WJ, Breitner JC, Cook DG. Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J Neurochem. 2004 Mar; 88(6):1361-72.

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Butchbach ME, Guo H, Lin CL. Methyl-beta-cyclodextrin but not retinoic acid reduces EAAT3-mediated glutamate uptake and increases GTRAP3-18 expression. J Neurochem. 2003 Feb; 84(4):891-4.

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Butchbach ME, Lai L, Lin CL. Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. Gene. 2002 Jun 12; 292(1-2):81-90.

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