Glutamate Plasma Membrane Transport Proteins
"Glutamate Plasma Membrane Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of plasma membrane neurotransmitter transporter proteins that couple the uptake of GLUTAMATE with the import of SODIUM ions and PROTONS and the export of POTASSIUM ions. In the CENTRAL NERVOUS SYSTEM they regulate neurotransmission through synaptic reuptake of the excitatory neurotransmitter glutamate. Outside the central nervous system they function as signal mediators and regulators of glutamate metabolism.
| Descriptor ID |
D050491
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| MeSH Number(s) |
D12.776.157.530.200.249.500.500 D12.776.157.530.450.625.147 D12.776.157.530.562.374.781 D12.776.157.530.937.250.500 D12.776.543.585.200.249.500.500 D12.776.543.585.450.625.147 D12.776.543.585.562.374.781 D12.776.543.585.937.250.500
|
| Concept/Terms |
Glutamate Plasma Membrane Transport Proteins- Glutamate Plasma Membrane Transport Proteins
- Neurotransmitter Transporters, Glutamate-Specific
- Glutamate-Specific Neurotransmitter Transporters
- Neurotransmitter Transporters, Glutamate Specific
- Transporters, Glutamate-Specific Neurotransmitter
- Neurotransmitter Transport Proteins, Glutamate-Specific
- Neurotransmitter Transport Proteins, Glutamate Specific
- Glutamate Plasma Membrane Transporter Proteins
Sodium-Glutamate Cotransporter- Sodium-Glutamate Cotransporter
- Cotransporter, Sodium-Glutamate
- Sodium Glutamate Cotransporter
- Sodium-Glutamate Transporter
- Sodium Glutamate Transporter
|
Below are MeSH descriptors whose meaning is more general than "Glutamate Plasma Membrane Transport Proteins".
Below are MeSH descriptors whose meaning is more specific than "Glutamate Plasma Membrane Transport Proteins".
This graph shows the total number of publications written about "Glutamate Plasma Membrane Transport Proteins" by people in this website by year, and whether "Glutamate Plasma Membrane Transport Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glutamate Plasma Membrane Transport Proteins" by people in Profiles.
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Rosenblum LT, Trotti D. EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis. Adv Neurobiol. 2017; 16:117-136.
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Li K, Javed E, Scura D, Hala TJ, Seetharam S, Falnikar A, Richard JP, Chorath A, Maragakis NJ, Wright MC, Lepore AC. Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury. Exp Neurol. 2015 Sep; 271:479-92.
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Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia. 2014 Aug; 62(8):1241-53.
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Foran E, Rosenblum L, Bogush AI, Trotti D. Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis. Neuromolecular Med. 2013 Dec; 15(4):760-70.
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Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem. 2006 May 19; 281(20):14076-84.
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Butchbach ME, Tian G, Guo H, Lin CL. Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function. J Biol Chem. 2004 Aug 13; 279(33):34388-96.
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Butchbach ME, Guo H, Lin CL. Methyl-beta-cyclodextrin but not retinoic acid reduces EAAT3-mediated glutamate uptake and increases GTRAP3-18 expression. J Neurochem. 2003 Feb; 84(4):891-4.
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Butchbach ME, Lai L, Lin CL. Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. Gene. 2002 Jun 12; 292(1-2):81-90.