Serotonin Plasma Membrane Transport Proteins

"Serotonin Plasma Membrane Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.

Descriptor ID	D050486
MeSH Number(s)	D12.776.157.530.450.625.311 D12.776.157.530.562.374.875 D12.776.157.530.937.624 D12.776.543.585.450.625.374 D12.776.543.585.562.374.875 D12.776.543.585.937.747
Concept/Terms	Serotonin Plasma Membrane Transport Proteins Serotonin Plasma Membrane Transport Proteins Serotonin Plasma Membrane Transporter Proteins Neurotransmitter Transporters, Serotonin-Specific Neurotransmitter Transporters, Serotonin Specific Serotonin-Specific Neurotransmitter Transporters 5-Hydroxytryptamine Plasma Membrane Transport Protein 5 Hydroxytryptamine Plasma Membrane Transport Protein Neurotransmitter Transport Proteins, Serotonin-Specific Neurotransmitter Transport Proteins, Serotonin Specific Serotonin Transporter SERT Proteins Solute Carrier Family 6, Member 4 Protein Solute Carrier Family 6, Member 4 Protein Sodium-Dependent Serotonin Transporter Serotonin Transporter, Sodium-Dependent Sodium Dependent Serotonin Transporter Transporter, Sodium-Dependent Serotonin 5HT Transporter SLC6A4 Protein Serotonectin Serotonectin Platelet Serotonin Transporter Serotonin Transporter, Platelet Serotonin Transporter, Platelets Platelets Serotonin Transporter

Below are MeSH descriptors whose meaning is more general than "Serotonin Plasma Membrane Transport Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Symporters [D12.776.157.530.450.625]
Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.450.625.311]
Neurotransmitter Transport Proteins [D12.776.157.530.562]
Plasma Membrane Neurotransmitter Transport Proteins [D12.776.157.530.562.374]
Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.562.374.875]
Solute Carrier Proteins [D12.776.157.530.937]
Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.937.624]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Symporters [D12.776.543.585.450.625]
Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.450.625.374]
Neurotransmitter Transport Proteins [D12.776.543.585.562]
Plasma Membrane Neurotransmitter Transport Proteins [D12.776.543.585.562.374]
Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.562.374.875]
Solute Carrier Proteins [D12.776.543.585.937]
Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.937.747]

Below are MeSH descriptors whose meaning is related to "Serotonin Plasma Membrane Transport Proteins".

Below are MeSH descriptors whose meaning is more specific than "Serotonin Plasma Membrane Transport Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Serotonin Plasma Membrane Transport Proteins" by people in this website by year, and whether "Serotonin Plasma Membrane Transport Proteins" was a major or minor topic of these publications.

Bar chart showing 21 publications over 11 distinct years, with a maximum of 3 publications in 2002 and 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	3	3
2003	0	3	3
2004	0	2	2
2005	1	1	2
2006	1	1	2
2008	2	0	2
2009	1	1	2
2010	0	1	1
2012	1	0	1
2013	2	0	2

Below are the most recent publications written about "Serotonin Plasma Membrane Transport Proteins" by people in Profiles.

Amsterdam JD, Newberg AB, Newman CF, Shults J, Wintering N, Soeller I. Change over time in brain serotonin transporter binding in major depression: effects of therapy measured with [(123) I]-ADAM SPECT. J Neuroimaging. 2013 Oct; 23(4):469-76.

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Matragrano LL, LeBlanc MM, Chitrapu A, Blanton ZE, Maney DL. Testosterone alters genomic responses to song and monoaminergic innervation of auditory areas in a seasonally breeding songbird. Dev Neurobiol. 2013 Jun; 73(6):455-68.

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Newberg AB, Amsterdam JD, Wintering N, Shults J. Low brain serotonin transporter binding in major depressive disorder. Psychiatry Res. 2012 May 31; 202(2):161-7.

View in: PubMed
Aboukhatwa MA, Undieh AS. Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition. BMC Neurosci. 2010 Jan 27; 11:10.

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Hayashi Y, Jacob-Vadakot S, Dugan EA, McBride S, Olexa R, Simansky K, Murray M, Shumsky JS. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats. Exp Neurol. 2010 Jan; 221(1):68-78.

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Lundgren JD, Amsterdam J, Newberg A, Allison KC, Wintering N, Stunkard AJ. Differences in serotonin transporter binding affinity in patients with major depressive disorder and night eating syndrome. Eat Weight Disord. 2009 Mar; 14(1):45-50.

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Jonnakuty C, Gragnoli C. What do we know about serotonin? J Cell Physiol. 2008 Nov; 217(2):301-6.

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Lundgren JD, Newberg AB, Allison KC, Wintering NA, Ploessl K, Stunkard AJ. 123I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report. Psychiatry Res. 2008 Apr 15; 162(3):214-20.

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Hatzenbuhler NT, Evrard DA, Harrison BL, Huryn D, Inghrim J, Kraml C, Mattes JF, Mewshaw RE, Zhou D, Hornby G, Lin Q, Smith DL, Sullivan KM, Schechter LE, Beyer CE, Andree TH. Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. J Med Chem. 2006 Jul 27; 49(15):4785-9.

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Deecher DC, Beyer CE, Johnston G, Bray J, Shah S, Abou-Gharbia M, Andree TH. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug; 318(2):657-65.

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