Cyclin-Dependent Kinase Inhibitor p21

"Cyclin-Dependent Kinase Inhibitor p21" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.

Descriptor ID	D050759
MeSH Number(s)	D12.644.360.225.500 D12.776.157.687.250 D12.776.167.187.500 D12.776.476.225.500 D12.776.624.776.355.500 D12.776.660.720.250
Concept/Terms	Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 Cyclin Dependent Kinase Inhibitor p21 CDKN1 Protein Senescent Cell-Derived Inhibitor Protein 1 Senescent Cell Derived Inhibitor Protein 1 Cell Cycle Regulator p21 Cyclin-Dependent Kinase Inhibitor 1A Protein Cyclin Dependent Kinase Inhibitor 1A Protein Cyclin Kinase Inhibitor p21 p21 Cyclin Kinase Inhibitor CDKN1A Protein Cdk-Interacting Protein 1 Cdk Interacting Protein 1 Cdk2 Inhibitor Protein CDK2-Associated Protein 20 kDa CDK2 Associated Protein 20 kDa p21 Cell Cycle Regulator

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p21".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]
Cyclin-Dependent Kinase Inhibitor p21 [D12.644.360.225.500]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.157.687.250]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.167.187]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.167.187.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.476.225.500]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.624.776.355.500]
Nuclear Proteins [D12.776.660]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.660.720.250]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinase Inhibitor p21".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p21".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor p21" was a major or minor topic of these publications.

Bar chart showing 27 publications over 16 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	2	2
1998	0	2	2
1999	0	1	1
2000	0	1	1
2002	0	1	1
2003	0	2	2
2004	0	2	2
2005	0	2	2
2006	0	1	1
2007	0	2	2
2008	0	1	1
2009	1	1	2
2011	1	1	2
2013	0	3	3
2019	1	0	1

Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in Profiles.

Taubenberger AV, Girardo S, Tr?ber N, Fischer-Friedrich E, Kr?ter M, Wagner K, Kurth T, Richter I, Haller B, Binner M, Hahn D, Freudenberg U, Werner C, Guck J. 3D Microenvironment Stiffness Regulates Tumor Spheroid Growth and Mechanics via p21 and ROCK. Adv Biosyst. 2019 09; 3(9):e1900128.

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Horv?th Z, Kovalszky I, Full?r A, Kiss K, Schaff Z, Iozzo RV, Baghy K. Decorin deficiency promotes hepatic carcinogenesis. Matrix Biol. 2014 Apr; 35:194-205.

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Baghy K, Horv?th Z, Regos E, Kiss K, Schaff Z, Iozzo RV, Kovalszky I. Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. FEBS J. 2013 May; 280(10):2150-64.

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Chen K, Wu K, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C, Addya S, Gormley M, Wang C, McMahon SB, Pestell RG. Dachshund binds p53 to block the growth of lung adenocarcinoma cells. Cancer Res. 2013 Jun 01; 73(11):3262-74.

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Londhe VA, Sundar IK, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I. Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung. Pediatr Res. 2011 May; 69(5 Pt 1):371-7.

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Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ. Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res. 2011 Apr; 26(4):747-60.

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Xiao L, Eto M, Kazanietz MG. ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. J Biol Chem. 2009 Oct 23; 284(43):29365-75.

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Cai KQ, Wu H, Klein-Szanto AJ, Xu XX. Acquisition of a second mutation of the Tp53 alleles immediately precedes epithelial morphological transformation in ovarian tumorigenicity. Gynecol Oncol. 2009 Jul; 114(1):18-25.

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Bi X, Tong C, Dockendorff A, Bancroft L, Gallagher L, Guzman G, Iozzo RV, Augenlicht LH, Yang W. Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis. 2008 Jul; 29(7):1435-40.

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Macias E, Kim Y, Miliani de Marval PL, Klein-Szanto A, Rodriguez-Puebla ML. Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. Cancer Res. 2007 Oct 15; 67(20):9713-20.

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