Gene Fusion

"Gene Fusion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The GENETIC RECOMBINATION of the parts of two or more GENES resulting in a gene with different or additional regulatory regions, or a new chimeric gene product. ONCOGENE FUSION includes an ONCOGENE as at least one of the fusion partners and such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS. ARTIFICIAL GENE FUSION is carried out in vitro by RECOMBINANT DNA technology.

Descriptor ID	D050939
MeSH Number(s)	G05.728.385
Concept/Terms	Gene Fusion Gene Fusion Fusion, Gene Fusions, Gene Gene Fusions

Below are MeSH descriptors whose meaning is more general than "Gene Fusion".

Biological Sciences [G]
Genetic Phenomena [G05]
Recombination, Genetic [G05.728]
Gene Fusion [G05.728.385]

Below are MeSH descriptors whose meaning is related to "Gene Fusion".

Below are MeSH descriptors whose meaning is more specific than "Gene Fusion".

Gene Fusion
Oncogene Fusion

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Fusion" by people in this website by year, and whether "Gene Fusion" was a major or minor topic of these publications.

Bar chart showing 13 publications over 8 distinct years, with a maximum of 3 publications in 2020 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	1	1
2012	0	1	1
2014	2	0	2
2015	0	1	1
2020	2	1	3
2021	0	1	1
2022	0	3	3
2023	1	0	1

Below are the most recent publications written about "Gene Fusion" by people in Profiles.

Patkar SS, Tang Y, Bisram AM, Zhang T, Saven JG, Pochan DJ, Kiick KL. Genetic Fusion of Thermoresponsive Polypeptides with UCST-type Behavior Mediates 1D Assembly of Coiled-Coil Bundlemers. Angew Chem Int Ed Engl. 2023 06 19; 62(25):e202301331.

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Yang JCH, Brose MS, Castro G, Kim ES, Lassen UN, Leyvraz S, Pappo A, L?pez-R?os F, Reeves JA, Fellous M, Penault-Llorca F, Rudzinski ER, Tabatabai G, Vassal G, Drilon A, Trent J. Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib. BMC Cancer. 2022 Jun 07; 22(1):625.

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Carlson JJ, Italiano A, Brose MS, Federman N, Lassen U, Kummar S, Sullivan SD. Comparative effectiveness of larotrectinib and entrectinib for TRK fusion cancer. Am J Manag Care. 2022 01; 28(2 Suppl):S26-S32.

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Kummar S, Italiano A, Brose MS, Carlson JJ, Sullivan SD, Lassen U, Federman N. Diagnosis and management of TRK fusion cancer. Am J Manag Care. 2022 01; 28(2 Suppl):S15-S25.

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Kruslin B, Gatalica Z, Hes O, Skenderi F, Miettinen M, Contreras E, Xiu J, Ellis M, Florento E, Vranic S, Swensen J. TERT Gene Fusions Characterize a Subset of Metastatic Leydig Cell Tumors. Clin Genitourin Cancer. 2021 08; 19(4):333-338.

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Righi A, Sbaraglia M, Gambarotti M, Gibertoni D, Rovira MP, Benini S, Errani C, Brenca M, Maestro R, Dei Tos AP. Primary Vascular Tumors of Bone: A Monoinstitutional Morphologic and Molecular Analysis of 427 Cases With Emphasis on Epithelioid Variants. Am J Surg Pathol. 2020 09; 44(9):1192-1203.

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Lasota J, Chlopek M, Wasag B, Kowalik A, Christiansen J, Lamoureux J, Kuzniacka A, Felisiak-Golabek A, Liu Y, Reyes TAR, Saha R, Agaimy A, Behenska K, Biernat W, Cattaneo L, Centonze G, Daum O, Daumova M, Domagala P, Dziuba I, Geppert CE, G?zdz S, Nasierowska-Guttmejer A, Halon A, Hartmann A, Inaguma S, Izycka-Swieszewska E, Kaczorowski M, Kolos M, Kopczynski J, Michal M, Milione M, Okon K, Peksa R, Pyzlak M, Rys J, Waloszczyk P, Wejman J, Miettinen M. Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature. Am J Surg Pathol. 2020 09; 44(9):1224-1234.

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Milman T, Ida CM, Zhang PJL, Eagle RC. Gene Fusions in Ocular Adnexal Tumors. Am J Ophthalmol. 2021 01; 221:211-225.

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Tomlins SA, Alshalalfa M, Davicioni E, Erho N, Yousefi K, Zhao S, Haddad Z, Den RB, Dicker AP, Trock BJ, DeMarzo AM, Ross AE, Schaeffer EM, Klein EA, Magi-Galluzzi C, Karnes RJ, Jenkins RB, Feng FY. Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes. Eur Urol. 2015 Oct; 68(4):555-67.

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Solomon DA, Brohl AS, Khan J, Miettinen M. Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion. Am J Surg Pathol. 2014 Dec; 38(12):1724-5.

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