"Staurosporine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
| Descriptor ID |
D019311
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| MeSH Number(s) |
D03.132.436.750 D03.633.100.473.144.750 D03.633.100.473.402.750 D03.633.300.148.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Staurosporine".
Below are MeSH descriptors whose meaning is more specific than "Staurosporine".
This graph shows the total number of publications written about "Staurosporine" by people in this website by year, and whether "Staurosporine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 2 | 3 |
| 2002 | 1 | 1 | 2 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Staurosporine" by people in Profiles.
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Khan MT, Bhanumathy CD, Schug ZT, Joseph SK. Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes. J Biol Chem. 2007 Nov 09; 282(45):32983-90.
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Khan MT, Wagner L, Yule DI, Bhanumathy C, Joseph SK. Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors. J Biol Chem. 2006 Feb 10; 281(6):3731-7.
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Weber GF, Menko AS. The canonical intrinsic mitochondrial death pathway has a non-apoptotic role in signaling lens cell differentiation. J Biol Chem. 2005 Jun 10; 280(23):22135-45.
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Tafani M, Cohn JA, Karpinich NO, Rothman RJ, Russo MA, Farber JL. Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. J Biol Chem. 2002 Dec 20; 277(51):49569-76.
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Prendergast GC. CHK and MEK inhibitors team up to trigger cancer cell suicide. Cancer Biol Ther. 2002 May-Jun; 1(3):254-5.
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Annis MG, Zamzami N, Zhu W, Penn LZ, Kroemer G, Leber B, Andrews DW. Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event. Oncogene. 2001 Apr 12; 20(16):1939-52.
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Tafani M, Minchenko DA, Serroni A, Farber JL. Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine. Cancer Res. 2001 Mar 15; 61(6):2459-66.
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White MK, Baireddy V, Strayer DS. Natural protection from apoptosis by surfactant protein A in type II pneumocytes. Exp Cell Res. 2001 Feb 15; 263(2):183-92.
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Chaqour B, Howard PS, Richards CF, Macarak EJ. Mechanical stretch induces platelet-activating factor receptor gene expression through the NF-kappaB transcription factor. J Mol Cell Cardiol. 1999 Jul; 31(7):1345-55.
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Eischen CM, Kottke TJ, Martins LM, Basi GS, Tung JS, Earnshaw WC, Leibson PJ, Kaufmann SH. Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions. Blood. 1997 Aug 01; 90(3):935-43.