Cyclin-Dependent Kinase 5
"Cyclin-Dependent Kinase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CELL DEATH of NERVE CELLS. It is closely related to other CYCLIN-DEPENDENT KINASES but does not seem to participate in CELL CYCLE regulation.
| Descriptor ID |
D051360
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.500.500 D12.644.360.250.067.875 D12.776.167.200.067.875 D12.776.476.250.067.875
|
| Concept/Terms |
Cyclin-Dependent Kinase 5- Cyclin-Dependent Kinase 5
- Cyclin Dependent Kinase 5
- Neuronal Cdc2-Like Protein Kinase
- Neuronal Cdc2 Like Protein Kinase
- Cdk5 Protein Kinase
- Protein Kinase, Cdk5
- Cdk5 Protein
- PSSALRE Protein
- Cdc2-Related Kinase PSSALRE
- Cdc2 Related Kinase PSSALRE
- PSSALRE, Cdc2-Related Kinase
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 5".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 5".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 5" by people in this website by year, and whether "Cyclin-Dependent Kinase 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 5" by people in Profiles.
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Saito T, Oba T, Shimizu S, Asada A, Iijima KM, Ando K. Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262. Hum Mol Genet. 2019 09 15; 28(18):3062-3071.
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Shupp A, Casimiro MC, Pestell RG. Biological functions of CDK5 and potential CDK5 targeted clinical treatments. Oncotarget. 2017 Mar 07; 8(10):17373-17382.
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Feldmann G, Mishra A, Hong SM, Bisht S, Strock CJ, Ball DW, Goggins M, Maitra A, Nelkin BD. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. Cancer Res. 2010 Jun 01; 70(11):4460-9.
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Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME. AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. J Biol Chem. 2007 Mar 09; 282(10):7352-9.
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Mantell LL, Shaffer TH, Horowitz S, Foust R, Wolfson MR, Cox C, Khullar P, Zakeri Z, Lin L, Kazzaz JA, Palaia T, Scott W, Davis JM. Distinct patterns of apoptosis in the lung during liquid ventilation compared with gas ventilation. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L31-41.
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Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T. Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. J Neurochem. 2000 Sep; 75(3):1085-91.
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Watanabe G, Pena P, Shambaugh GE, Haines GK, Pestell RG. Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development. Brain Res Dev Brain Res. 1998 Jun 15; 108(1-2):77-87.