CDC2 Protein Kinase

"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.

Descriptor ID	D016203
MeSH Number(s)	D08.811.913.696.620.682.700.646.500.500.250 D08.811.913.696.620.682.700.646.500.984.500 D12.644.360.250.067.249 D12.644.360.250.580.500 D12.776.167.200.067.249 D12.776.167.200.580.500 D12.776.476.250.067.249 D12.776.476.250.580.500 D12.776.744.360
Concept/Terms	CDC2 Protein Kinase CDC2 Protein Kinase Protein Kinase, CDC2 Cdk1 Protein Kinase Protein Kinase, Cdk1 cdk1 Kinase cdc2+ Protein Cyclin-Dependent Kinase 1 Cyclin Dependent Kinase 1 p34cdc2 Protein p34cdc2 Protein Protein p34cdc2 p34cdc2, Protein Histone Kinase p34(cdc2)

Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.500.250]
Maturation-Promoting Factor [D08.811.913.696.620.682.700.646.500.984]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.984.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
CDC2-CDC28 Kinases [D12.644.360.250.067]
CDC2 Protein Kinase [D12.644.360.250.067.249]
Maturation-Promoting Factor [D12.644.360.250.580]
CDC2 Protein Kinase [D12.644.360.250.580.500]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
CDC2-CDC28 Kinases [D12.776.167.200.067]
CDC2 Protein Kinase [D12.776.167.200.067.249]
Maturation-Promoting Factor [D12.776.167.200.580]
CDC2 Protein Kinase [D12.776.167.200.580.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]
CDC2-CDC28 Kinases [D12.776.476.250.067]
CDC2 Protein Kinase [D12.776.476.250.067.249]
Maturation-Promoting Factor [D12.776.476.250.580]
CDC2 Protein Kinase [D12.776.476.250.580.500]
Phosphoproteins [D12.776.744]
CDC2 Protein Kinase [D12.776.744.360]

Below are MeSH descriptors whose meaning is related to "CDC2 Protein Kinase".

Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in this website by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1999	0	1	1
2003	1	0	1
2006	0	1	1
2007	1	0	1
2008	0	1	1
2010	1	0	1
2014	0	1	1
2015	3	0	3
2019	1	0	1

Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.

Pippa R, Boffo S, Odero MD, Giordano A. Data mining analysis of the PP2A cell cycle axis in mesothelioma patients. J Cell Physiol. 2020 06; 235(6):5284-5292.

View in: PubMed
Helms MC, Grabocka E, Martz MK, Fischer CC, Suzuki N, Wedegaertner PB. Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1. Cell Signal. 2016 Jan; 28(1):43-52.

View in: PubMed
Afonso DJ, Liu D, Machado DR, Pan H, Jepson JE, Rogulja D, Koh K. TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila. Curr Biol. 2015 Jun 29; 25(13):1717-26.

View in: PubMed
Afonso DJ, Machado DR, Koh K. Control of sleep by a network of cell cycle genes. Fly (Austin). 2015; 9(4):165-72.

View in: PubMed
Corbi D, Sunder S, Weinreich M, Skokotas A, Johnson ES, Winter E. Multisite phosphorylation of the Sum1 transcriptional repressor by S-phase kinases controls exit from meiotic prophase in yeast. Mol Cell Biol. 2014 Jun; 34(12):2249-63.

View in: PubMed
Shin ME, Skokotas A, Winter E. The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor. Mol Cell Biol. 2010 Jun; 30(12):2996-3003.

View in: PubMed
Rodriguez-Collazo P, Snyder SK, Chiffer RC, Bressler EA, Voss TC, Anderson EP, Genieser HG, Smith CL. cAMP signaling regulates histone H3 phosphorylation and mitotic entry through a disruption of G2 progression. Exp Cell Res. 2008 Sep 10; 314(15):2855-69.

View in: PubMed
Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 2007 Mar; 11(3):275-89.

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Ujiki MB, Ding XZ, Salabat MR, Bentrem DJ, Golkar L, Milam B, Talamonti MS, Bell RH, Iwamura T, Adrian TE. Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol Cancer. 2006 Dec 29; 5:76.

View in: PubMed
Manes T, Zheng DQ, Tognin S, Woodard AS, Marchisio PC, Languino LR. Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol. 2003 May 26; 161(4):817-26.

View in: PubMed

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