"KCNQ Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of delayed rectifier voltage-gated potassium channels that share homology with their founding member, KCNQ1 PROTEIN. KCNQ potassium channels have been implicated in a variety of diseases including LONG QT SYNDROME; DEAFNESS; and EPILEPSY.
| Descriptor ID |
D051656
|
| MeSH Number(s) |
D12.776.157.530.400.600.900.124.249 D12.776.543.550.450.750.900.124.249 D12.776.543.585.400.750.900.124.249
|
| Concept/Terms |
KCNQ Potassium Channels- KCNQ Potassium Channels
- Potassium Channels, KCNQ
- KvLQT Potassium Channels
- Potassium Channels, KvLQT
|
Below are MeSH descriptors whose meaning is more general than "KCNQ Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "KCNQ Potassium Channels".
This graph shows the total number of publications written about "KCNQ Potassium Channels" by people in this website by year, and whether "KCNQ Potassium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "KCNQ Potassium Channels" by people in Profiles.
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Gao L, Fei H, Connors NC, Zhang J, Levitan IB. Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels. J Neurophysiol. 2008 May; 99(5):2736-40.
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Wen H, Weiger TM, Ferguson TS, Shahidullah M, Scott SS, Levitan IB. A Drosophila KCNQ channel essential for early embryonic development. J Neurosci. 2005 Nov 02; 25(44):10147-56.
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Casimiro MC, Knollmann BC, Yamoah EN, Nie L, Vary JC, Sirenko SG, Greene AE, Grinberg A, Huang SP, Ebert SN, Pfeifer K. Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans. Genomics. 2004 Sep; 84(3):555-64.
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Knollmann BC, Casimiro MC, Katchman AN, Sirenko SG, Schober T, Rong Q, Pfeifer K, Ebert SN. Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current. J Pharmacol Exp Ther. 2004 Jul; 310(1):311-8.
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Tosaka T, Casimiro MC, Rong Q, Tella S, Oh M, Katchman AN, Pezzullo JC, Pfeifer K, Ebert SN. Nicotine induces a long QT phenotype in Kcnq1-deficient mouse hearts. J Pharmacol Exp Ther. 2003 Sep; 306(3):980-7.
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Ramakers C, Vos MA, Doevendans PA, Schoenmakers M, Wu YS, Scicchitano S, Iodice A, Thomas GP, Antzelevitch C, Dumaine R. Coordinated down-regulation of KCNQ1 and KCNE1 expression contributes to reduction of I(Ks) in canine hypertrophied hearts. Cardiovasc Res. 2003 Feb; 57(2):486-96.
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Franco D, Demolombe S, Kupershmidt S, Dumaine R, Dominguez JN, Roden D, Antzelevitch C, Escande D, Moorman AF. Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development. Cardiovasc Res. 2001 Oct; 52(1):65-75.
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Antzelevitch C. Molecular biology and cellular mechanisms of Brugada and long QT syndromes in infants and young children. J Electrocardiol. 2001; 34 Suppl:177-81.
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Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation. 1998 Nov 24; 98(21):2314-22.