Delayed Rectifier Potassium Channels
"Delayed Rectifier Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics they play an important role in controlling ACTION POTENTIAL duration.
| Descriptor ID |
D051668
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| MeSH Number(s) |
D12.776.157.530.400.600.900.124 D12.776.543.550.450.750.900.124 D12.776.543.585.400.750.900.124
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Delayed Rectifier Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "Delayed Rectifier Potassium Channels".
This graph shows the total number of publications written about "Delayed Rectifier Potassium Channels" by people in this website by year, and whether "Delayed Rectifier Potassium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 4 | 4 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Delayed Rectifier Potassium Channels" by people in Profiles.
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Burashnikov A, Belardinelli L, Antzelevitch C. Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation. Heart Rhythm. 2015 Apr; 12(4):836-44.
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Pavri BB, Greenberg HE, Kraft WK, Lazarus N, Lynch JJ, Salata JJ, Bilodeau MT, Regan CP, Stump G, Fan L, Mehta A, Wagner JA, Gutstein DE, Bloomfield D. MK-0448, a specific Kv1.5 inhibitor: safety, pharmacokinetics, and pharmacodynamic electrophysiology in experimental animal models and humans. Circ Arrhythm Electrophysiol. 2012 Dec; 5(6):1193-201.
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Burashnikov A, Antzelevitch C. Can inhibition of IKur promote atrial fibrillation? Heart Rhythm. 2008 Sep; 5(9):1304-9.
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Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation. 2004 Aug 24; 110(8):904-10.
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Burashnikov A, Mannava S, Antzelevitch C. Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect of IKr and IKur/Ito block. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2393-400.
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Fish JM, Di Diego JM, Nesterenko V, Antzelevitch C. Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing. Circulation. 2004 May 04; 109(17):2136-42.
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Knollmann BC, Casimiro MC, Katchman AN, Sirenko SG, Schober T, Rong Q, Pfeifer K, Ebert SN. Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current. J Pharmacol Exp Ther. 2004 Jul; 310(1):311-8.
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Xu X, Salata JJ, Wang J, Wu Y, Yan GX, Liu T, Marinchak RA, Kowey PR. Increasing I(Ks) corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H664-70.
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Sun ZQ, Thomas GP, Antzelevitch C. Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J Cardiovasc Electrophysiol. 2001 Apr; 12(4):472-8.
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Xu X, Rials SJ, Wu Y, Salata JJ, Liu T, Bharucha DB, Marinchak RA, Kowey PR. Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits. Circulation. 2001 Mar 20; 103(11):1585-90.