Transforming Growth Factor beta2

"Transforming Growth Factor beta2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.

Descriptor ID	D053781
MeSH Number(s)	D12.644.276.374.687.200 D12.644.276.954.775.200 D12.776.467.374.687.200 D12.776.467.942.775.200 D23.529.374.687.200 D23.529.942.775.200
Concept/Terms	Transforming Growth Factor beta2 Transforming Growth Factor beta2 Glioblastoma-Derived T-Cell Suppressor Factor Glioblastoma Derived T Cell Suppressor Factor Cartilage-Inducing Factor-B Cartilage Inducing Factor B Polyergin TGF-beta2 TGF-beta-2 BSC-1 Cell Growth Inhibitor BSC 1 Cell Growth Inhibitor Suppressor Factor, T-Cell, Glioblastoma-Derived Transforming Growth Factor beta 2 Latency Associated Peptide Transforming Growth Factor beta 2 Latency Associated Peptide TGF-beta2LAP TGF beta2LAP TGF-beta2 Latency-Associated Protein Latency-Associated Protein, TGF-beta2 TGF beta2 Latency Associated Protein

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Transforming Growth Factor beta [D12.644.276.374.687]
Transforming Growth Factor beta2 [D12.644.276.374.687.200]
TGF-beta Superfamily Proteins [D12.644.276.954]
Transforming Growth Factor beta [D12.644.276.954.775]
Transforming Growth Factor beta2 [D12.644.276.954.775.200]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Transforming Growth Factor beta [D12.776.467.374.687]
Transforming Growth Factor beta2 [D12.776.467.374.687.200]
TGF-beta Superfamily Proteins [D12.776.467.942]
Transforming Growth Factor beta [D12.776.467.942.775]
Transforming Growth Factor beta2 [D12.776.467.942.775.200]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Transforming Growth Factor beta [D23.529.374.687]
Transforming Growth Factor beta2 [D23.529.374.687.200]
TGF-beta Superfamily Proteins [D23.529.942]
Transforming Growth Factor beta [D23.529.942.775]
Transforming Growth Factor beta2 [D23.529.942.775.200]

Below are MeSH descriptors whose meaning is related to "Transforming Growth Factor beta2".

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor beta2" by people in this website by year, and whether "Transforming Growth Factor beta2" was a major or minor topic of these publications.

Bar chart showing 17 publications over 13 distinct years, with a maximum of 2 publications in 2013 and 2014 and 2015 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2003	0	1	1
2006	0	1	1
2007	1	0	1
2009	0	1	1
2011	0	1	1
2013	2	0	2
2014	1	1	2
2015	0	2	2
2020	1	0	1
2021	1	1	2
2022	0	1	1
2024	1	0	1

Below are the most recent publications written about "Transforming Growth Factor beta2" by people in Profiles.

Quintanilha JCF, Sibley AB, Liu Y, Niedzwiecki D, Halabi S, Rogers L, O'Neil B, Kindler H, Kelly W, Venook A, McLeod HL, Ratain MJ, Nixon AB, Innocenti F, Owzar K. Common variation in a long non-coding RNA gene modulates variation of circulating TGF-?2 levels in metastatic colorectal cancer patients (Alliance). BMC Genomics. 2024 May 14; 25(1):473.

View in: PubMed
Adulla A, Patel U, Ashok A, Katiyar P, Kaulakis M, Kritikos AE, Pillai S, Lee H, Lindner E, Rhee DJ, Singh N. a-Synuclein modulates fibronectin expression in the trabecular meshwork independent of TGF?2. Exp Eye Res. 2023 01; 226:109351.

View in: PubMed
Schneider M, Dillinger AE, Ohlmann A, Iozzo RV, Fuchshofer R. Decorin-An Antagonist of TGF-? in Astrocytes of the Optic Nerve. Int J Mol Sci. 2021 Jul 17; 22(14).

View in: PubMed
Manukian G, Kivolowitz C, DeAngelis T, Shastri AA, Savage JE, Camphausen K, Rodeck U, Zarif JC, Simone NL. Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells. Int J Radiat Oncol Biol Phys. 2021 08 01; 110(5):1341-1349.

View in: PubMed
Ashok A, Chaudhary S, Kritikos AE, Kang MH, McDonald D, Rhee DJ, Singh N. TGF?2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology. Invest Ophthalmol Vis Sci. 2020 03 09; 61(3):24.

View in: PubMed
Thalji NM, Hagler MA, Zhang H, Casaclang-Verzosa G, Nair AA, Suri RM, Miller JD. Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve Disease. Circ Cardiovasc Genet. 2015 Jun; 8(3):516-28.

View in: PubMed
Vu LT, Keschrumrus V, Zhang X, Zhong JF, Su Q, Kabeer MH, Loudon WG, Li SC. Tissue elasticity regulated tumor gene expression: implication for diagnostic biomarkers of primitive neuroectodermal tumor. PLoS One. 2015; 10(3):e0120336.

View in: PubMed
Swaminathan SS, Oh DJ, Kang MH, Shepard AR, Pang IH, Rhee DJ. TGF-?2-mediated ocular hypertension is attenuated in SPARC-null mice. Invest Ophthalmol Vis Sci. 2014 Jun 06; 55(7):4084-97.

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Chatterjee A, Villarreal G, Oh DJ, Kang MH, Rhee DJ. AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork. Invest Ophthalmol Vis Sci. 2014 Apr 08; 55(5):3127-39.

View in: PubMed
Mony S, Lee SJ, Harper JF, Barwe SP, Langhans SA. Regulation of Na,K-ATPase ?1-subunit in TGF-?2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells. Exp Eye Res. 2013 Oct; 115:113-22.

View in: PubMed

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