Gene Knockdown Techniques

"Gene Knockdown Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.

Descriptor ID	D055785
MeSH Number(s)	E05.393.335.500
Concept/Terms	Gene Knockdown Techniques Gene Knockdown Techniques Gene Knockdown Technique Knockdown Technique, Gene Knockdown Techniques, Gene Technique, Gene Knockdown Techniques, Gene Knockdown Gene Knockdown Gene Knockdowns Knockdown, Gene Knockdowns, Gene Gene Knock-Down Gene Knock-Downs Knock-Down, Gene Knock-Downs, Gene Gene Knock-Down Techniques Gene Knock-Down Technique Knock-Down Technique, Gene Knock-Down Techniques, Gene Technique, Gene Knock-Down Techniques, Gene Knock-Down Gene Knock Down Gene Knock Downs Knock Down, Gene Knock Downs, Gene Gene Knock Down Techniques

Below are MeSH descriptors whose meaning is more general than "Gene Knockdown Techniques".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]
Gene Knockdown Techniques [E05.393.335.500]

Below are MeSH descriptors whose meaning is related to "Gene Knockdown Techniques".

Below are MeSH descriptors whose meaning is more specific than "Gene Knockdown Techniques".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Knockdown Techniques" by people in this website by year, and whether "Gene Knockdown Techniques" was a major or minor topic of these publications.

Bar chart showing 142 publications over 15 distinct years, with a maximum of 25 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2009	0	12	12
2010	0	11	11
2011	0	11	11
2012	0	11	11
2013	2	23	25
2014	0	10	10
2015	1	10	11
2016	0	6	6
2017	0	11	11
2018	0	5	5
2019	0	9	9
2020	0	12	12
2021	0	6	6
2025	0	1	1

Below are the most recent publications written about "Gene Knockdown Techniques" by people in Profiles.

Islam R, Roche ME, Lin Z, Whitaker-Menezes D, Diaz-Barros V, Serrano E, Martinez Cantarin MP, Philp NJ, Basu Mallick A, Martinez-Outschoorn U. TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis. Mol Oncol. 2025 Aug; 19(8):2431-2455.

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Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA, Penn RB, Kambayashi T, Deshpande DA. Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling. Am J Respir Cell Mol Biol. 2021 12; 65(6):658-671.

View in: PubMed
Darga EP, Dolce EM, Fang F, Kidwell KM, Gersch CL, Kregel S, Thomas DG, Gill A, Brown ME, Gross S, Connelly M, Holinstat M, Cobain EF, Rae JM, Hayes DF, Paoletti C. PD-L1 expression on circulating tumor cells and platelets in patients with metastatic breast cancer. PLoS One. 2021; 16(11):e0260124.

View in: PubMed
Mandigo AC, Shafi AA, McCann JJ, Yuan W, Laufer TS, Bogdan D, Gallagher L, Dylgjeri E, Semenova G, Vasilevskaya IA, Schiewer MJ, McNair CM, de Bono JS, Knudsen KE. Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer. Cancer Res. 2022 01 15; 82(2):221-234.

View in: PubMed
Lu Z, Ortiz A, Verginadis II, Peck AR, Zahedi F, Cho C, Yu P, DeRita RM, Zhang H, Kubanoff R, Sun Y, Yaspan AT, Krespan E, Beiting DP, Radaelli E, Ryeom SW, Diehl JA, Rui H, Koumenis C, Fuchs SY. Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. J Clin Invest. 2021 05 17; 131(10).

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Kim S, Lee ES, Lee EJ, Jung JY, Lee SB, Lee HJ, Kim J, Kim HJ, Lee JW, Son BH, Gong G, Ahn SH, Chang S. Targeted eicosanoids profiling reveals a prostaglandin reprogramming in breast Cancer by microRNA-155. J Exp Clin Cancer Res. 2021 Jan 25; 40(1):43.

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Youssefian L, Niaziorimi F, Saeidian AH, South AP, Khosravi-Bachehmir F, Khodavaisy S, Vahidnezhad H, Uitto J. Knockdown of SDR9C7 Impairs Epidermal Barrier Function. J Invest Dermatol. 2021 07; 141(7):1754-1764.e1.

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Sanders SS, Hernandez LM, Soh H, Karnam S, Walikonis RS, Tzingounis AV, Thomas GM. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Elife. 2020 11 13; 9.

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Layer JV, Debaize L, Van Scoyk A, House NC, Brown AJ, Liu Y, Stevenson KE, Hemann M, Roberts SA, Price BD, Weinstock DM, Day TA. Polymerase d promotes chromosomal rearrangements and imprecise double-strand break repair. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27566-27577.

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Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O'Connell RM, Rondina MT, Campbell RA, Bray PF. miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin. Blood. 2020 10 08; 136(15):1760-1772.

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