Gene Knock-In Techniques

"Gene Knock-In Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques used to add in exogenous gene sequence such as mutated genes; REPORTER GENES, to study mechanisms of gene expression; or regulatory control sequences, to study effects of temporal changes to GENE EXPRESSION.

Descriptor ID	D055879
MeSH Number(s)	E05.393.335.249
Concept/Terms	Gene Knock-In Techniques Gene Knock-In Techniques Gene Knock-In Technique Knock-In Technique, Gene Knock-In Techniques, Gene Technique, Gene Knock-In Techniques, Gene Knock-In Gene Knock-In Gene Knock-Ins Knock-In, Gene Knock-Ins, Gene Gene Knock In Gene Knock Ins In, Gene Knock Ins, Gene Knock Knock In, Gene Knock Ins, Gene Gene Knock In Techniques

Below are MeSH descriptors whose meaning is more general than "Gene Knock-In Techniques".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]
Gene Knock-In Techniques [E05.393.335.249]

Below are MeSH descriptors whose meaning is related to "Gene Knock-In Techniques".

Below are MeSH descriptors whose meaning is more specific than "Gene Knock-In Techniques".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Knock-In Techniques" by people in this website by year, and whether "Gene Knock-In Techniques" was a major or minor topic of these publications.

Bar chart showing 38 publications over 16 distinct years, with a maximum of 5 publications in 2008 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	4	5
2009	0	1	1
2010	0	5	5
2011	0	3	3
2012	0	3	3
2013	0	1	1
2014	0	3	3
2015	1	3	4
2016	0	1	1
2017	0	2	2
2018	1	2	3
2019	1	1	2
2020	0	1	1
2021	0	2	2
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "Gene Knock-In Techniques" by people in Profiles.

Khalife MR, Villarin C, Ruiz JM, McClelland SA, Rabbo KA, Matthew Mahoney J, Scott RC, Hernan AE. Melanocortin 4 Receptor-Dependent Mechanism of ACTH in Preventing Anxiety-Like Behaviors and Normalizing Astrocyte Proteins after Early Life Seizures. eNeuro. 2025 Mar; 12(3).

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Han X, Knauss EA, Fuente M, Li W, Conlon RA, LePage DF, Jiang W, Renna SA, McKenzie SE, Nieman MT. A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity. J Thromb Haemost. 2024 06; 22(6):1715-1726.

View in: PubMed
Merlo LMF, Peng W, DuHadaway JB, Montgomery JD, Prendergast GC, Muller AJ, Mandik-Nayak L. The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism. J Immunol. 2022 02 01; 208(3):571-581.

View in: PubMed
Sakakibara Y, Hirota Y, Ibaraki K, Takei K, Chikamatsu S, Tsubokawa Y, Saito T, Saido TC, Sekiya M, Iijima KM. Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-? Amyloidosis. J Alzheimers Dis. 2021; 82(4):1513-1530.

View in: PubMed
Cho KJ, Ishido S, Eisenlohr LC, Roche PA. Activation of Dendritic Cells Alters the Mechanism of MHC Class II Antigen Presentation to CD4 T Cells. J Immunol. 2020 03 15; 204(6):1621-1629.

View in: PubMed
Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Amyloid-? plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. BMC Neurosci. 2019 Mar 20; 20(1):13.

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Korecki AJ, Hickmott JW, Lam SL, Dreolini L, Mathelier A, Baker O, Kuehne C, Bonaguro RJ, Smith J, Tan CV, Zhou M, Goldowitz D, Deussing JM, Stewart AF, Wasserman WW, Holt RA, Simpson EM. Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele. Genetics. 2019 04; 211(4):1155-1177.

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Brennan-Crispi DM, Overmiller AM, Tamayo-Orrego L, Marous MR, Sahu J, McGuinn KP, Cooper F, Georgiou IC, Frankfurter M, Salas-Alanis JC, Charron F, Millar SE, Mahoney MG, Riobo-Del Galdo NA. Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression. J Invest Dermatol. 2019 02; 139(2):300-307.

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Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Cognitive and emotional alterations in App knock-in mouse models of A? amyloidosis. BMC Neurosci. 2018 07 28; 19(1):46.

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Hayakawa K, Formica AM, Nakao Y, Ichikawa D, Shinton SA, Brill-Dashoff J, Smith MR, Morse HC, Hardy RR. Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. J Immunol. 2018 07 15; 201(2):804-813.

View in: PubMed

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