"Cathepsin K" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Descriptor ID |
D056657
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MeSH Number(s) |
D08.811.277.656.224.405 D08.811.277.656.262.500.156 D08.811.277.656.300.200.156
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cathepsin K".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin K".
This graph shows the total number of publications written about "Cathepsin K" by people in this website by year, and whether "Cathepsin K" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2000 | 0 | 2 | 2 |
2002 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2007 | 0 | 1 | 1 |
2015 | 0 | 1 | 1 |
2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cathepsin K" by people in Profiles.
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McGlinchey RP, Lacy SM, Walker RL, Lee JC. Cathepsin K is a potent disaggregase of a-synuclein fibrils. Biochem Biophys Res Commun. 2020 09 03; 529(4):1106-1111.
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Schultz TC, Valenzano JP, Verzella JL, Umland EM. Odanacatib: an emerging novel treatment alternative for postmenopausal osteoporosis. Womens Health (Lond). 2015 Nov; 11(6):805-14.
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Hassanein M, Xue F, Seto CT, Mason RW. Development of a specific inhibitor for the placental protease, cathepsin P. Arch Biochem Biophys. 2007 Aug 15; 464(2):288-94.
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Puzer L, Barros NM, Oliveira V, Juliano MA, Lu G, Hassanein M, Juliano L, Mason RW, Carmona AK. Defining the substrate specificity of mouse cathepsin P. Arch Biochem Biophys. 2005 Mar 01; 435(1):190-6.
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Mason RW, Bergman CA, Lu G, Frenck Holbrook J, Sol-Church K. Expression and characterization of cathepsin P. Biochem J. 2004 Mar 01; 378(Pt 2):657-63.
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Sol-Church K, Picerno GN, Stabley DL, Frenck J, Xing S, Bertenshaw GP, Mason RW. Evolution of placentally expressed cathepsins. Biochem Biophys Res Commun. 2002 Apr 26; 293(1):23-9.
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Sol-Church K, Frenck J, Mason RW. Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P. Biochim Biophys Acta. 2000 Apr 25; 1491(1-3):289-94.
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Sol-Church K, Frenck J, Mason RW. Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta. Biochem Biophys Res Commun. 2000 Jan 27; 267(3):791-5.
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Sol-Church K, Frenck J, Troeber D, Mason RW. Cathepsin P, a novel protease in mouse placenta. Biochem J. 1999 Oct 15; 343 Pt 2:307-9.