"Cathepsin B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
| Descriptor ID |
D002401
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| MeSH Number(s) |
D08.811.277.656.224.125 D08.811.277.656.262.500.133 D08.811.277.656.300.200.133
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin B".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin B".
This graph shows the total number of publications written about "Cathepsin B" by people in this website by year, and whether "Cathepsin B" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 2 | 3 |
| 1999 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cathepsin B" by people in Profiles.
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Cartledge DM, Colella R, Glazewski L, Lu G, Mason RW. Inhibitors of cathepsins B and L induce autophagy and cell death in neuroblastoma cells. Invest New Drugs. 2013 Feb; 31(1):20-9.
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Colella R, Lu G, Glazewski L, Korant B, Matlapudi A, England MR, Craft C, Frantz CN, Mason RW. Induction of cell death in neuroblastoma by inhibition of cathepsins B and L. Cancer Lett. 2010 Aug 28; 294(2):195-203.
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Qian J, Bostwick DG, Iczkowski KA, Betre K, Wilson MJ, LE C, Sinha AA. Characterization of prostate cancer in needle biopsy by cathepsin B, cell proliferation and DNA ploidy. Anticancer Res. 2010 Mar; 30(3):719-25.
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Motlekar N, Diamond SL, Napper AD. Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay Drug Dev Technol. 2008 Jun; 6(3):395-405.
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Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett. 2007 Sep 01; 17(17):4761-6.
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Qiu Z, Hingley ST, Simmons G, Yu C, Das Sarma J, Bates P, Weiss SR. Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry. J Virol. 2006 Jun; 80(12):5768-76.
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Sol-Church K, Shipley J, Beckman DA, Mason RW. Expression of cysteine proteases in extraembryonic tissues during mouse embryogenesis. Arch Biochem Biophys. 1999 Dec 15; 372(2):375-81.
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Xing R, Mason RW. Design of a transferrin-proteinase inhibitor conjugate to probe for active cysteine proteinases in endosomes. Biochem J. 1998 Dec 15; 336 ( Pt 3):667-73.
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Xing R, Addington AK, Mason RW. Quantification of cathepsins B and L in cells. Biochem J. 1998 Jun 01; 332 ( Pt 2):499-505.
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Mason RW, Sol-Church K, Abrahamson M. Amino acid substitutions in the N-terminal segment of cystatin C create selective protein inhibitors of lysosomal cysteine proteinases. Biochem J. 1998 Mar 01; 330 ( Pt 2):833-8.