"Bicuculline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
| Descriptor ID |
D001640
|
| MeSH Number(s) |
D03.132.098.077 D03.633.100.531.085.077
|
| Concept/Terms |
Bicuculline- Bicuculline
- 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
|
Below are MeSH descriptors whose meaning is more general than "Bicuculline".
Below are MeSH descriptors whose meaning is more specific than "Bicuculline".
This graph shows the total number of publications written about "Bicuculline" by people in this website by year, and whether "Bicuculline" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Bicuculline" by people in Profiles.
-
Hernan AE, Alexander A, Lenck-Santini PP, Scott RC, Holmes GL. Attention deficit associated with early life interictal spikes in a rat model is improved with ACTH. PLoS One. 2014; 9(2):e89812.
-
Monnerie H, Hsu FC, Coulter DA, Le Roux PD. Role of the NR2A/2B subunits of the N-methyl-D-aspartate receptor in glutamate-induced glutamic acid decarboxylase alteration in cortical GABAergic neurons in vitro. Neuroscience. 2010 Dec 29; 171(4):1075-90.
-
Brailoiu GC, Brailoiu E, Chang JK, Dun NJ. Excitatory effects of human immunodeficiency virus 1 Tat on cultured rat cerebral cortical neurons. Neuroscience. 2008 Feb 06; 151(3):701-10.
-
Kandov Y, Israel Y, Kest A, Dostova I, Verasammy J, Bernal SY, Kasselman L, Bodnar RJ. GABA receptor subtype antagonists in the nucleus accumbens shell and ventral tegmental area differentially alter feeding responses induced by deprivation, glucoprivation and lipoprivation in rats. Brain Res. 2006 Apr 12; 1082(1):86-97.
-
Wu SY, Ohtubo Y, Brailoiu GC, Dun NJ. Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices. Br J Pharmacol. 2003 Nov; 140(6):1088-96.
-
Benardete EA, Kriegstein AR. Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex. Epilepsia. 2002 Sep; 43(9):970-82.
-
Watanabe S, Jimbo Y, Kamioka H, Kirino Y, Kawana A. Development of low magnesium-induced spontaneous synchronized bursting and GABAergic modulation in cultured rat neocortical neurons. Neurosci Lett. 1996 May 24; 210(1):41-4.
-
Feng HS, Lynn RB, Han J, Brooks FP. Gastric effects of TRH analogue and bicuculline injected into dorsal motor vagal nucleus in cats. Am J Physiol. 1990 Aug; 259(2 Pt 1):G321-6.