Complement Pathway, Alternative
"Complement Pathway, Alternative" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003170
|
| MeSH Number(s) |
G12.274.695
|
| Concept/Terms |
Complement Pathway, Alternative- Complement Pathway, Alternative
- Alternative Complement Pathway
- Alternative Complement Activation Pathway
- Properdin Pathway
- Complement Activation Pathway, Alternative
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Alternative".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Alternative".
This graph shows the total number of publications written about "Complement Pathway, Alternative" by people in this website by year, and whether "Complement Pathway, Alternative" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Pathway, Alternative" by people in Profiles.
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Yaspan BL, Williams DF, Holz FG, Regillo CD, Li Z, Dressen A, van Lookeren Campagne M, Le KN, Graham RR, Beres T, Bhangale TR, Honigberg LA, Smith A, Henry EC, Ho C, Strauss EC. Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration. Sci Transl Med. 2017 06 21; 9(395).
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Liboro R, Schwartz AB, Conroy J, Conroy J, Brezin J, Vanderlinde RE, Krevolin L, Brodsky I. Heparin free hemodialysis does not cause fibrin consumptive coagulopathy and maintains alternate pathway complement activation. ASAIO Trans. 1990 Apr-Jun; 36(2):86-9.
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Abraham D, Grieve RB, Mika-Grieve M. Dirofilaria immitis: surface properties of third- and fourth-stage larvae. Exp Parasitol. 1988 Apr; 65(2):157-67.
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Kew RR, Ghebrehiwet B, Janoff A. The role of complement in cigarette smoke-induced chemotactic activity of lung fluids. Am Rev Respir Dis. 1986 Mar; 133(3):478-81.
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Webster GF, McArthur WP. Activation of components of the alternative pathway of complement by Propionibacterium acnes cell wall carbohydrate. J Invest Dermatol. 1982 Sep; 79(3):137-40.