Complement Pathway, Classical
"Complement Pathway, Classical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003171
|
| MeSH Number(s) |
G12.274.698
|
| Concept/Terms |
Complement Pathway, Classical- Complement Pathway, Classical
- Classical Complement Activation Pathway
- Complement Activation Pathway, Classical
- Classical Complement Pathway
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Classical".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Classical".
This graph shows the total number of publications written about "Complement Pathway, Classical" by people in this website by year, and whether "Complement Pathway, Classical" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Pathway, Classical" by people in Profiles.
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Quast I, Keller CW, Maurer MA, Giddens JP, Tackenberg B, Wang LX, M?nz C, Nimmerjahn F, Dalakas MC, L?nemann JD. Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity. J Clin Invest. 2015 Nov 02; 125(11):4160-70.
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Merritt TA, Hallman M, Holcomb K, Strayer D, Bloom B, Revak S, Cochrane CG. Human surfactant treatment of severe respiratory distress syndrome: pulmonary effluent indicators of lung inflammation. J Pediatr. 1986 May; 108(5 Pt 1):741-8.
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Verbrugh HA, Lee DA, Elliott GR, Keane WF, Hoidal JR, Peterson PK. Opsonization of Legionella pneumophila in human serum: key roles for specific antibodies and the classical complement pathway. Immunology. 1985 Apr; 54(4):643-53.