"Huntington Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Descriptor ID |
D006816
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| MeSH Number(s) |
C10.228.140.079.545 C10.228.140.380.278 C10.228.662.262.249.750 C10.574.500.497 C16.320.400.430 F03.615.250.400 F03.615.400.390
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| Concept/Terms |
Huntington Disease- Huntington Disease
- Huntington Chorea
- Chorea, Huntington
- Huntington's Disease
- Chronic Progressive Hereditary Chorea (Huntington)
- Huntington Chronic Progressive Hereditary Chorea
- Progressive Chorea, Chronic Hereditary (Huntington)
- Progressive Chorea, Hereditary, Chronic (Huntington)
- Huntington's Chorea
- Chorea, Huntington's
- Chorea, Chronic Progressive Hereditary (Huntington)
Juvenile Huntington Disease- Juvenile Huntington Disease
- Juvenile-Onset Huntington Disease
- Juvenile Onset Huntington Disease
- Huntington Disease, Juvenile-Onset
- Huntington Disease, Juvenile Onset
- Huntington Disease, Juvenile
|
Below are MeSH descriptors whose meaning is more general than "Huntington Disease".
Below are MeSH descriptors whose meaning is more specific than "Huntington Disease".
This graph shows the total number of publications written about "Huntington Disease" by people in this website by year, and whether "Huntington Disease" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Huntington Disease" by people in Profiles.
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Zhi L, Zhao J, Jaffe D, Chen Y, Wang N, Qin Q, Seifert EL, Li C, Zhang H. Measurement of Oxygen Consumption Rate in Acute Striatal Slices from Adult Mice. J Vis Exp. 2022 Jun 08; (184).
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Gupta S, Jie S, Colby DW. Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay. J Biol Chem. 2012 Mar 23; 287(13):9982-9.
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Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH, Pasinelli P, Trotti D. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. J Biol Chem. 2007 Nov 2; 282(44):32480-90.
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Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME. AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. J Biol Chem. 2007 Mar 9; 282(10):7352-9.
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Armen RS, Bernard BM, Day R, Alonso DO, Daggett V. Characterization of a possible amyloidogenic precursor in glutamine-repeat neurodegenerative diseases. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13433-8.
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Colby DW, Chu Y, Cassady JP, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram VM, Wittrup KD. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17616-21.
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Luthi-Carter R, Strand AD, Hanson SA, Kooperberg C, Schilling G, La Spada AR, Merry DE, Young AB, Ross CA, Borchelt DR, Olson JM. Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects. Hum Mol Genet. 2002 Aug 15; 11(17):1927-37.