Immunoglobulin Fc Fragments

"Immunoglobulin Fc Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Descriptor ID	D007141
MeSH Number(s)	D12.644.541.500.697 D12.776.124.486.485.538.500 D12.776.124.486.485.680.697 D12.776.124.790.651.538.500 D12.776.124.790.651.680.660 D12.776.377.715.548.538.500 D12.776.377.715.548.680.660
Concept/Terms	Immunoglobulin Fc Fragments Immunoglobulin Fc Fragments Fc Fragments, Immunoglobulin Immunoglobulins, Fc Fragment Fc Fragment Immunoglobulins Fragment Immunoglobulins, Fc Immunoglobulin Fc Fragment Fc Fragment, Immunoglobulin Immunoglobulins, Fc Fc Fragments Fc Immunoglobulins

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fc Fragments".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fc Fragments [D12.644.541.500.697]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Constant Regions [D12.776.124.486.485.538]
Immunoglobulin Fc Fragments [D12.776.124.486.485.538.500]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fc Fragments [D12.776.124.486.485.680.697]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Constant Regions [D12.776.124.790.651.538]
Immunoglobulin Fc Fragments [D12.776.124.790.651.538.500]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fc Fragments [D12.776.124.790.651.680.660]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Constant Regions [D12.776.377.715.548.538]
Immunoglobulin Fc Fragments [D12.776.377.715.548.538.500]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fc Fragments [D12.776.377.715.548.680.660]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Fc Fragments".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fc Fragments".

Immunoglobulin Fc Fragments
CD4 Immunoadhesins

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Fc Fragments" by people in this website by year, and whether "Immunoglobulin Fc Fragments" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2003	1	0	1
2005	1	0	1
2009	2	1	3
2010	0	1	1
2013	2	0	2
2014	1	0	1
2015	2	0	2
2018	1	0	1

Below are the most recent publications written about "Immunoglobulin Fc Fragments" by people in Profiles.

Kitchen S, Jennings I, Makris M, Kitchen DP, Woods TAL, Walker ID. Clotting and chromogenic factor VIII assay variability in post-infusion and spiked samples containing full-length recombinant FVIII or recombinant factor VIII Fc fusion protein (rFVIIIFc). Int J Lab Hematol. 2019 Apr; 41(2):176-183.

View in: PubMed
Carlson K, Pomerantz SC, Vafa O, Naso M, Strohl W, Mains RE, Eipper BA. Optimizing production of Fc-amidated peptides by Chinese hamster ovary cells. BMC Biotechnol. 2015 Oct 16; 15:95.

View in: PubMed
Carlson KR, Pomerantz SC, Li J, Vafa O, Naso M, Strohl W, Mains RE, Eipper BA. Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells. BMC Biotechnol. 2015 Jun 27; 15:61.

View in: PubMed
Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, Whitten JA, Park SM, Korontsvit T, Zakhaleva V, Casey E, Curcio M, Kharas MG, O'Reilly RJ, Liu C, Scheinberg DA. Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein. Clin Cancer Res. 2014 Aug 01; 20(15):4036-46.

View in: PubMed
Bendell JC, Gordon MS, Hurwitz HI, Jones SF, Mendelson DS, Blobe GC, Agarwal N, Condon CH, Wilson D, Pearsall AE, Yang Y, McClure T, Attie KM, Sherman ML, Sharma S. Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer. Clin Cancer Res. 2014 Jan 15; 20(2):480-9.

View in: PubMed
Park IK, Trotta R, Yu J, Caligiuri MA. Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development. Eur J Immunol. 2013 Oct; 43(10):2750-5.

View in: PubMed
Naso MF, Tam SH, Scallon BJ, Raju TS. Engineering host cell lines to reduce terminal sialylation of secreted antibodies. MAbs. 2010 Sep-Oct; 2(5):519-27.

View in: PubMed
Benny Klimek ME, Aydogdu T, Link MJ, Pons M, Koniaris LG, Zimmers TA. Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1548-54.

View in: PubMed
Awan FT, Lapalombella R, Trotta R, Butchar JP, Yu B, Benson DM, Roda JM, Cheney C, Mo X, Lehman A, Jones J, Flynn J, Jarjoura D, Desjarlais JR, Tridandapani S, Caligiuri MA, Muthusamy N, Byrd JC. CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood. 2010 Feb 11; 115(6):1204-13.

View in: PubMed
Terai M, Tamura Y, Alexeev V, Ohtsuka E, Berd D, Mastrangelo MJ, Sato T. Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential. Cancer Immunol Immunother. 2009 Aug; 58(8):1307-17.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement