Immunoglobulin Fc Fragments

"Immunoglobulin Fc Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Descriptor ID	D007141
MeSH Number(s)	D12.644.541.500.697 D12.776.124.486.485.538.500 D12.776.124.486.485.680.697 D12.776.124.790.651.538.500 D12.776.124.790.651.680.660 D12.776.377.715.548.538.500 D12.776.377.715.548.680.660
Concept/Terms	Immunoglobulin Fc Fragments Immunoglobulin Fc Fragments Fc Fragments, Immunoglobulin Immunoglobulins, Fc Fragment Fc Fragment Immunoglobulins Fragment Immunoglobulins, Fc Immunoglobulin Fc Fragment Fc Fragment, Immunoglobulin Immunoglobulins, Fc Fc Fragments Fc Immunoglobulins

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fc Fragments".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fc Fragments [D12.644.541.500.697]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Constant Regions [D12.776.124.486.485.538]
Immunoglobulin Fc Fragments [D12.776.124.486.485.538.500]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fc Fragments [D12.776.124.486.485.680.697]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Constant Regions [D12.776.124.790.651.538]
Immunoglobulin Fc Fragments [D12.776.124.790.651.538.500]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fc Fragments [D12.776.124.790.651.680.660]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Constant Regions [D12.776.377.715.548.538]
Immunoglobulin Fc Fragments [D12.776.377.715.548.538.500]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fc Fragments [D12.776.377.715.548.680.660]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Fc Fragments".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fc Fragments".

Immunoglobulin Fc Fragments
CD4 Immunoadhesins

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Fc Fragments" by people in this website by year, and whether "Immunoglobulin Fc Fragments" was a major or minor topic of these publications.

Bar chart showing 61 publications over 24 distinct years, with a maximum of 7 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	1	0	1
2001	1	4	5
2003	1	0	1
2005	1	0	1
2006	1	1	2
2007	0	1	1
2008	1	2	3
2009	3	1	4
2010	1	1	2
2011	1	0	1
2012	1	0	1
2013	4	0	4
2014	4	3	7
2015	3	1	4
2016	1	0	1
2017	5	0	5
2018	5	0	5
2019	1	0	1
2020	1	1	2
2021	1	1	2
2022	0	1	1
2023	0	3	3
2024	3	0	3

Below are the most recent publications written about "Immunoglobulin Fc Fragments" by people in Profiles.

Reddy JV, Leibiger T, Singh SK, Lee KH, Papoutsakis E, Ierapetritou M. A Novel, Site-Specific N-Linked Glycosylation Model Provides Mechanistic Insights Into the Process-Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells. Biotechnol Bioeng. 2025 04; 122(4):761-778.

View in: PubMed
Reddy JV, Singh SK, Leibiger T, Lee KH, Ierapetritou M, Papoutsakis ET. Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese hamster ovary (CHO) cell metabolism and N-linked glycosylation in the fab and Fc regions of the produced IgG. Metab Eng. 2025 Jan; 87:37-48.

View in: PubMed
Jabbour S, Paik JS, Aleppo G, Sharma P, Gomez Valderas E, Benneyworth BD. Switching to Tirzepatide 5?mg From Glucagon-Like Peptide-1 Receptor Agonists: Clinical Expectations in the First 12 Weeks of Treatment. Endocr Pract. 2024 Aug; 30(8):701-709.

View in: PubMed
Guillet B, Yan S, Hooper B, Drelich D, Steenkamp J, Tomic R, Mancuso ME. Matching-Adjusted Indirect Comparison of Recombinant Factor?IX Albumin Fusion Protein Versus Recombinant Factor?IX Fc Fusion Protein for Weekly Prophylactic Treatment of Hemophilia?B. Adv Ther. 2024 02; 41(2):649-658.

View in: PubMed
Wong JL, Smith P, Angulo-Lozano J, Ranti D, Bochner BH, Sfakianos JP, Horowitz A, Ravetch JV, Knorr DA. IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2306782120.

View in: PubMed
Gupta A, Kao KS, Yamin R, Oren DA, Goldgur Y, Du J, Lollar P, Sundberg EJ, Ravetch JV. Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody. Nat Commun. 2023 05 18; 14(1):2853.

View in: PubMed
Kao KS, Gupta A, Zong G, Li C, Kerschbaumer I, Borghi S, Achkar JM, Bournazos S, Wang LX, Ravetch JV. Synthetic nanobodies as tools to distinguish IgG Fc glycoforms. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2212658119.

View in: PubMed
Yamin R, Jones AT, Hoffmann HH, Sch?fer A, Kao KS, Francis RL, Sheahan TP, Baric RS, Rice CM, Ravetch JV, Bournazos S. Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy. Nature. 2021 11; 599(7885):465-470.

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Bournazos S, Vo HTM, Duong V, Auerswald H, Ly S, Sakuntabhai A, Dussart P, Cantaert T, Ravetch JV. Antibody fucosylation predicts disease severity in secondary dengue infection. Science. 2021 06 04; 372(6546):1102-1105.

View in: PubMed
Bournazos S, Corti D, Virgin HW, Ravetch JV. Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection. Nature. 2020 12; 588(7838):485-490.

View in: PubMed

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