Immunoglobulin Fc Fragments

"Immunoglobulin Fc Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Descriptor ID	D007141
MeSH Number(s)	D12.644.541.500.697 D12.776.124.486.485.538.500 D12.776.124.486.485.680.697 D12.776.124.790.651.538.500 D12.776.124.790.651.680.660 D12.776.377.715.548.538.500 D12.776.377.715.548.680.660
Concept/Terms	Immunoglobulin Fc Fragments Immunoglobulin Fc Fragments Fc Fragments, Immunoglobulin Immunoglobulins, Fc Fragment Fc Fragment Immunoglobulins Fragment Immunoglobulins, Fc Immunoglobulin Fc Fragment Fc Fragment, Immunoglobulin Immunoglobulins, Fc Fc Fragments Fc Immunoglobulins

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fc Fragments".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fc Fragments [D12.644.541.500.697]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Constant Regions [D12.776.124.486.485.538]
Immunoglobulin Fc Fragments [D12.776.124.486.485.538.500]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fc Fragments [D12.776.124.486.485.680.697]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Constant Regions [D12.776.124.790.651.538]
Immunoglobulin Fc Fragments [D12.776.124.790.651.538.500]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fc Fragments [D12.776.124.790.651.680.660]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Constant Regions [D12.776.377.715.548.538]
Immunoglobulin Fc Fragments [D12.776.377.715.548.538.500]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fc Fragments [D12.776.377.715.548.680.660]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Fc Fragments".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fc Fragments".

Immunoglobulin Fc Fragments
CD4 Immunoadhesins

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Fc Fragments" by people in this website by year, and whether "Immunoglobulin Fc Fragments" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2003	1	0	1
2005	1	0	1
2009	2	1	3
2010	0	1	1
2013	2	0	2
2014	1	0	1
2015	2	0	2
2018	1	0	1

Below are the most recent publications written about "Immunoglobulin Fc Fragments" by people in Profiles.

Wong JL, Smith P, Angulo-Lozano J, Ranti D, Bochner BH, Sfakianos JP, Horowitz A, Ravetch JV, Knorr DA. IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2306782120.

View in: PubMed
Gupta A, Kao KS, Yamin R, Oren DA, Goldgur Y, Du J, Lollar P, Sundberg EJ, Ravetch JV. Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody. Nat Commun. 2023 05 18; 14(1):2853.

View in: PubMed
Kao KS, Gupta A, Zong G, Li C, Kerschbaumer I, Borghi S, Achkar JM, Bournazos S, Wang LX, Ravetch JV. Synthetic nanobodies as tools to distinguish IgG Fc glycoforms. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2212658119.

View in: PubMed
Yamin R, Jones AT, Hoffmann HH, Sch?fer A, Kao KS, Francis RL, Sheahan TP, Baric RS, Rice CM, Ravetch JV, Bournazos S. Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy. Nature. 2021 11; 599(7885):465-470.

View in: PubMed
Bournazos S, Vo HTM, Duong V, Auerswald H, Ly S, Sakuntabhai A, Dussart P, Cantaert T, Ravetch JV. Antibody fucosylation predicts disease severity in secondary dengue infection. Science. 2021 06 04; 372(6546):1102-1105.

View in: PubMed
Bournazos S, Corti D, Virgin HW, Ravetch JV. Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection. Nature. 2020 12; 588(7838):485-490.

View in: PubMed
Van Rompay KKA, Coffey LL, Kapoor T, Gazumyan A, Keesler RI, Jurado A, Peace A, Agudelo M, Watanabe J, Usachenko J, Singapuri A, Immareddy R, Ardeshir A, Stuart JB, Bournazos S, Ravetch JV, Balderes PJ, Lorenz IC, Esswein SR, Keeffe JR, Bjorkman PJ, Wang Q, Rice CM, MacDonald MR, Nussenzweig MC, Robbiani DF. A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7981-7989.

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Wang TT, Ravetch JV. Functional diversification of IgGs through Fc glycosylation. J Clin Invest. 2019 09 03; 129(9):3492-3498.

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Kitchen S, Jennings I, Makris M, Kitchen DP, Woods TAL, Walker ID. Clotting and chromogenic factor VIII assay variability in post-infusion and spiked samples containing full-length recombinant FVIII or recombinant factor VIII Fc fusion protein (rFVIIIFc). Int J Lab Hematol. 2019 Apr; 41(2):176-183.

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Giddens JP, Lomino JV, DiLillo DJ, Ravetch JV, Wang LX. Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):12023-12027.

View in: PubMed

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