Immunoglobulin Fab Fragments

"Immunoglobulin Fab Fragments" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Descriptor ID	D007140
MeSH Number(s)	D12.644.541.500.650 D12.776.124.486.485.680.650 D12.776.124.790.651.680.650 D12.776.377.715.548.680.650
Concept/Terms	Immunoglobulin Fab Fragments Immunoglobulin Fab Fragments Fab Fragments, Immunoglobulin Immunoglobulins, Fab Fragment Fab Fragment Immunoglobulins Fragment Immunoglobulins, Fab Immunoglobulin Fab Fragment Fab Fragment, Immunoglobulin Fab Immunoglobulin Fragments Immunoglobulin Fragments, Fab Fab Fragments Immunoglobulins, Fab

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Fab Fragments".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Fab Fragments".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Fab Fragments".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Fab Fragments" by people in this website by year, and whether "Immunoglobulin Fab Fragments" was a major or minor topic of these publications.

Bar chart showing 44 publications over 23 distinct years, with a maximum of 7 publications in 1999

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	2	1	3
1998	2	0	2
1999	6	1	7
2000	2	0	2
2001	1	0	1
2002	2	0	2
2003	1	2	3
2005	0	1	1
2006	0	1	1
2007	0	2	2
2008	1	1	2
2009	1	1	2
2010	1	2	3
2011	1	0	1
2013	0	1	1
2014	0	1	1
2016	0	1	1
2017	1	1	2
2018	1	0	1
2020	1	0	1
2023	0	1	1
2024	1	2	3

Below are the most recent publications written about "Immunoglobulin Fab Fragments" by people in Profiles.

Reddy JV, Leibiger T, Singh SK, Lee KH, Papoutsakis E, Ierapetritou M. A Novel, Site-Specific N-Linked Glycosylation Model Provides Mechanistic Insights Into the Process-Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells. Biotechnol Bioeng. 2025 04; 122(4):761-778.

View in: PubMed
Reddy JV, Singh SK, Leibiger T, Lee KH, Ierapetritou M, Papoutsakis ET. Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese hamster ovary (CHO) cell metabolism and N-linked glycosylation in the fab and Fc regions of the produced IgG. Metab Eng. 2025 Jan; 87:37-48.

View in: PubMed
Shaheen A, Ashkenazy N, Magraner M, Patel NA, Fortun J, Rosenfeld PJ, Schwartz SG, Haddock LJ, Dubovy SR, Sridhar J, Yehoshua Z, Kovach JL, Townsend JH, Smiddy WE, Flynn HW, Yannuzzi NA. Faricimab in Previously Treated Eyes With Neovascular Age-Related Macular Degeneration: An Assessment of Durability and Treatment Outcomes. Ophthalmic Surg Lasers Imaging Retina. 2024 09; 55(9):504-509.

View in: PubMed
Bolton MJ, Santos JJS, Arevalo CP, Griesman T, Watson M, Li SH, Bates P, Ramage H, Wilson PC, Hensley SE. IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2216521120.

View in: PubMed
Lokareddy RK, Ko YH, Hong N, Doll SG, Paduch M, Niederweis M, Kossiakoff AA, Cingolani G. Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment. Acta Crystallogr D Struct Biol. 2020 Sep 01; 76(Pt 9):876-888.

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Giddens JP, Lomino JV, DiLillo DJ, Ravetch JV, Wang LX. Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):12023-12027.

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Yaspan BL, Williams DF, Holz FG, Regillo CD, Li Z, Dressen A, van Lookeren Campagne M, Le KN, Graham RR, Beres T, Bhangale TR, Honigberg LA, Smith A, Henry EC, Ho C, Strauss EC. Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration. Sci Transl Med. 2017 06 21; 9(395).

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Bournazos S, Ravetch JV. Anti-retroviral antibody Fc?R-mediated effector functions. Immunol Rev. 2017 01; 275(1):285-295.

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Bournazos S, Gazumyan A, Seaman MS, Nussenzweig MC, Ravetch JV. Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency. Cell. 2016 Jun 16; 165(7):1609-1620.

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Wu H, Kroe-Barrett R, Singh S, Robinson AS, Roberts CJ. Competing aggregation pathways for monoclonal antibodies. FEBS Lett. 2014 Mar 18; 588(6):936-41.

View in: PubMed

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